Soria-Utrilla Virginia, Piñar-Gutiérrez Ana, Sánchez-Torralvo Francisco José, Adarve-Castro Antonio, Porras Nuria, Jiménez-Sánchez Andrés, Quintana-Gallego María Esther, Olveira Casilda, Girón María Victoria, Olveira Gabriel, García-Luna Pedro Pablo
Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, 29016 Málaga, Spain.
Nutrients. 2025 Sep 12;17(18):2940. doi: 10.3390/nu17182940.
Computed Tomography (CT) is considered a highly accurate tool for assessing body composition. The aim of this study is to assess the usefulness of chest CT for malnutrition diagnosis in people with cystic fibrosis (PwCF), compared with other body composition techniques, as well as to assess possible associations with nutritional and respiratory status. : A cross-sectional study was carried out in clinically stable adult PwCF. Subjects who had undergone a CT including the twelfth thoracic vertebra (T12) during the 6 months prior to or after our assessment were included and body composition was assessed using FocusedON-BC. The results were compared with anthropometry, bioelectrical impedance analysis (BIA), muscle ultrasonography, and handgrip strength (HGS). Respiratory parameters were collected, and nutritional status was assessed using Global Leadership Initiative on Malnutrition (GLIM) criteria. : A total of 55 PwCF were included. Muscle area assessed by CT correlated significantly with fat-free mass determined by BIA ( = 0.725) and anthropometry ( = 0.645), muscle mass evaluated by ultrasonography ( = 0.657), HGS ( = 0.593), Bhalla score ( = 0.403), and FEV1 ( = 0.488). Differences were observed when comparing muscle area in CT based on the Bhalla score (94.6 ± 21.1 cm in normal/mild involvement vs. 79.3 ± 20.9 cm in moderate/severe involvement; = 0.009) and on nutritional status (96.3 ± 17.9 cm in normo-nourished vs. 75.9 ± 22.1 cm in malnourished; < 0.001). : In adult PwCF, measurements obtained from CT image analysis correlate adequately with anthropometry, BIA, muscle ultrasound, and HGS. Muscle area in CT is related to nutritional and respiratory status.
计算机断层扫描（CT）被认为是评估身体成分的一种高度准确的工具。本研究的目的是评估胸部CT在诊断囊性纤维化患者（PwCF）营养不良方面的效用，并与其他身体成分分析技术进行比较，同时评估其与营养和呼吸状况的可能关联。：对临床稳定的成年PwCF患者进行了一项横断面研究。纳入在我们评估前或后的6个月内接受过包括第十二胸椎（T12）的CT检查的受试者，并使用FocusedON-BC评估身体成分。将结果与人体测量、生物电阻抗分析（BIA）、肌肉超声检查和握力（HGS）进行比较。收集呼吸参数，并使用全球营养不良领导倡议（GLIM）标准评估营养状况。：总共纳入了55名PwCF患者。CT评估的肌肉面积与BIA测定的去脂体重（r = 0.725）、人体测量（r = 0.645）、超声检查评估的肌肉质量（r = 0.657）、HGS（r = 0.593）、巴拉评分（r = 0.403）和第一秒用力呼气容积（FEV1）（r = 0.488）显著相关。根据巴拉评分比较CT中的肌肉面积时观察到差异（正常/轻度受累者为94.6±21.1平方厘米，中度/重度受累者为79.3±20.9平方厘米；p = 0.009），以及根据营养状况比较时也有差异（营养正常者为96.3±17.9平方厘米，营养不良者为75.9±22.1平方厘米；p < 0.001）。：在成年PwCF患者中，从CT图像分析获得的测量结果与人体测量、BIA、肌肉超声和HGS有充分的相关性。CT中的肌肉面积与营养和呼吸状况有关。
