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吲哚菁绿血管造影术在血栓闭塞性脉管炎所致动脉溃疡患者手术截肢平面评估中的应用

Indocyanine Green Angiography in the Evaluation of Surgical Amputation Level in Patients with Arterial Ulcers Due to Thromboangiitis Obliterans.

作者信息

Akyüz Simay, Güven Hikmet Erhan, Yılmaz Kerim Bora

机构信息

Department of Oncology Nursing, Gulhane Faculty of Nursing, University of Health Sciences, Ankara 06010, Turkey.

Department of General Surgery, Diabetic Foot and Chronic Wounds, University of Health Sciences, Etlik City Hospital, Ankara 06010, Turkey.

出版信息

Medicina (Kaunas). 2025 Sep 16;61(9):1678. doi: 10.3390/medicina61091678.

DOI:10.3390/medicina61091678
PMID:41011069
Abstract

: The aim of this study was to evaluate the role of Indocyanine Green Angiography (ICGA) on amputation levels and the wound healing process in patients with thromboangiitis obliterans (TAO) and complex diabetes. : The research was conducted on 26 inpatients, with TAO and lower extremity ulcers, who were treated between November 2019 and September 2021. A retrospective analysis was made of overall health status, wound characteristics, and surgical outcomes. : The patients comprised 88.5% males and 11.5% females, with a mean age of 62.31 years. In 84.6% of the patients evaluated with ICG angiography, the wound healing process was achieved with no complications. Negative and positive correlations were identified between ICG density values and wound healing time, disease-free follow-up time, and ICG full density time. : These findings suggest that ICG angiography may assist in achieving safe surgical margins for patients with TAO. In conclusion, ICG angiography can be considered a valuable predictive tool for assessing tissue perfusion in TAO-related lower extremity ulcers.

摘要

本研究旨在评估吲哚菁绿血管造影(ICGA)在血栓闭塞性脉管炎(TAO)合并复杂性糖尿病患者截肢平面及伤口愈合过程中的作用。本研究对2019年11月至2021年9月期间接受治疗的26例患有TAO和下肢溃疡的住院患者进行。对总体健康状况、伤口特征和手术结果进行了回顾性分析。患者中男性占88.5%,女性占11.5%,平均年龄为62.31岁。在84.6%接受ICG血管造影评估的患者中,伤口愈合过程顺利,无并发症。ICG密度值与伤口愈合时间、无病随访时间及ICG全密度时间之间存在负相关和正相关。这些发现表明,ICGA可能有助于为TAO患者实现安全的手术切缘。总之,ICGA可被视为评估TAO相关下肢溃疡组织灌注的有价值的预测工具。

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本文引用的文献

1
Current Opinion on Diagnosis of Peripheral Artery Disease in Diabetic Patients.糖尿病患者外周动脉疾病诊断的现状观点。
Medicina (Kaunas). 2024 Jul 20;60(7):1179. doi: 10.3390/medicina60071179.
2
Diagnosis and treatment of diabetic foot ulcer complicated with lower extremity vasculopathy: Consensus recommendation from the Chinese Medical Association (CMA), Chinese Medical Doctor Association (CMDA).糖尿病足溃疡合并下肢血管病变的诊断与治疗:中华医学会、中国医师协会专家共识。
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Diagnostic criteria for Buerger's disease: International Consensus of VAS - European Independent Foundation in Angiology/Vascular Medicine.
伯格氏病的诊断标准:VAS-欧洲血管医学独立基金会国际共识。
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Recent advances of oxidative stress in thromboangiitis obliterans: biomolecular mechanisms, biomarkers, sources and clinical applications.血栓闭塞性脉管炎氧化应激的最新进展:生物分子机制、生物标志物、来源及临床应用。
Thromb Res. 2023 Oct;230:64-73. doi: 10.1016/j.thromres.2023.08.015. Epub 2023 Aug 25.
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Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update).《糖尿病相关足部疾病预防与管理实用指南(IWGDF 2023 更新版)》。
Diabetes Metab Res Rev. 2024 Mar;40(3):e3657. doi: 10.1002/dmrr.3657. Epub 2023 May 27.
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What Is Currently the Role of TcPO2 in the Choice of the Amputation Level of Lower Limbs? A Comprehensive Review.目前经皮氧分压(TcPO2)在下肢截肢平面选择中扮演着怎样的角色?一项综述
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The incidence, prevalence, and survival rate of thromboangiitis obliterans in Korea: a retrospective population-based study.韩国血栓闭塞性脉管炎的发病率、患病率及生存率:一项基于人群的回顾性研究。
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8
Intraoperative Indocyanine Green Fluorescence Angiography Is Sensitive for Predicting Postoperative Wound Complications in Soft-Tissue Sarcoma Surgery.术中吲哚菁绿荧光血管造影术对软组织肉瘤手术后伤口并发症具有较高的预测敏感性。
J Am Acad Orthop Surg. 2021 May 15;29(10):433-438. doi: 10.5435/JAAOS-D-20-00355.
9
Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices: A Scientific Statement From the American Heart Association.严重肢体缺血的灌注评估:理解原则、证据开发和设备评估:美国心脏协会的科学声明。
Circulation. 2019 Sep 17;140(12):e657-e672. doi: 10.1161/CIR.0000000000000708. Epub 2019 Aug 12.
10
Applicability of Transcutaneous Oxygen Tension Measurement in the Assessment of Chronic Limb-Threatening Ischemia.经皮氧分压测量在慢性肢体威胁性缺血评估中的适用性。
Angiology. 2020 Mar;71(3):208-216. doi: 10.1177/0003319719866958. Epub 2019 Aug 6.