Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Thromb Res. 2023 Oct;230:64-73. doi: 10.1016/j.thromres.2023.08.015. Epub 2023 Aug 25.
Oxidative stress (OS) has been identified as a key factor in the development of Thromboangiitis Obliterans (TAO). The detection of OS levels in clinical and scientific research practice is mainly based on the measurement of oxidative stress such as reactive oxygen species (ROS), reactive nitrogen species (RNS) and lipid peroxides. These markers are typically assessed through a combination of physical and chemical methods. Smoking is known to the state of OS in TAO, and OS levels are significantly increased in smokers due to inadequate antioxidant protection, which leads to the expression of apoptotic proteins and subsequent cell injury, thrombosis and limb ischemia. There, understanding the role of OS in the pathogenesis of TAO may provide insights into the etiology of TAO and a basis for its prevention and treatment.
氧化应激（OS）已被确定为血栓闭塞性脉管炎（TAO）发展的关键因素。在临床和科学研究实践中，OS 水平的检测主要基于氧化应激标志物如活性氧（ROS）、活性氮（RNS）和脂质过氧化物的测量。这些标志物通常通过物理和化学方法的组合进行评估。吸烟被认为是 TAO 中的 OS 状态，由于抗氧化保护不足，吸烟者的 OS 水平显著升高，导致凋亡蛋白的表达和随后的细胞损伤、血栓形成和肢体缺血。因此，了解 OS 在 TAO 发病机制中的作用可能有助于深入了解 TAO 的病因，并为其预防和治疗提供依据。
