Dikmeer Ayse, Eren Funda, Neselioglu Salim, Sahiner Zeynep, Hafizoglu Merve, Karaduman Didem, Atbas Cansu, Ileri Ibrahim, Dogu Burcu Balam, Cankurtaran Mustafa, Akbiyik Filiz, Erel Ozcan, Halil Meltem Gulhan
Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, 06230 Ankara, Türkiye.
Department of Clinical Biochemistry, Ankara Bilkent City Hospital, 06800 Ankara, Türkiye.
Medicina (Kaunas). 2025 Sep 19;61(9):1708. doi: 10.3390/medicina61091708.
Sarcopenic obesity (SO), characterized by the coexistence of excess adiposity and reduced muscle mass/function, is associated with adverse outcomes in older adults. Oxidative stress has been implicated in the pathogenesis of both obesity and sarcopenia. This study aimed to evaluate the association between thiol/disulfide homeostasis (TDH), ischemia-modified albumin (IMA), and SO in obese older adults. In this cross-sectional study, 132 obese individuals aged ≥65 years were enrolled from a geriatrics outpatient clinic. SO was defined based on the ESPEN/EASO criteria, incorporating anthropometric, body composition, and muscle function measures. Serum native and total thiol levels, disulfide concentrations, and IMA were assessed. Logistic regression identified independent predictors of SO, and ROC analysis evaluated the discriminatory power of oxidative parameters. SO was present in 15.2% ( = 20) of participants. Patients with SO exhibited significantly lower native ( = 0.003) and total thiol levels ( < 0.001), and higher disulfide/native thiol ( = 0.009) and disulfide/total thiol ratios ( = 0.009). IMA levels were slightly elevated in SO but not significantly different ( = 0.13). In multivariable regression, age and disulfide/native thiol ratio were independent predictors of SO (OR = 5.71, = 0.041). ROC analysis showed that disulfide/native thiol ratio had moderate predictive accuracy (AUC = 0.684, = 0.008), with a cut-off > 6.63 yielding 92.86% specificity. Older adults with SO exhibit disrupted redox balance, as evidenced by altered TDH parameters. The disulfide/native thiol ratio may serve as a useful oxidative biomarker for identifying SO. These findings highlight the potential role of oxidative stress in SO and warrant further research into targeted antioxidant strategies.
肌少性肥胖（SO）的特征是肥胖与肌肉量/功能减少并存，与老年人的不良后果相关。氧化应激与肥胖和肌少症的发病机制均有关联。本研究旨在评估硫醇/二硫键稳态（TDH）、缺血修饰白蛋白（IMA）与肥胖老年人SO之间的关联。在这项横断面研究中，从老年门诊招募了132名年龄≥65岁的肥胖个体。SO根据ESPEN/EASO标准定义，纳入人体测量、身体成分和肌肉功能指标。评估血清天然和总硫醇水平、二硫键浓度及IMA。逻辑回归确定SO的独立预测因素，ROC分析评估氧化参数的判别能力。15.2%（n = 20）的参与者存在SO。SO患者的天然硫醇水平（P = 0.003）和总硫醇水平显著更低（P < 0.001），二硫键/天然硫醇比值（P = 0.009）和二硫键/总硫醇比值更高（P = 0.009）。SO患者的IMA水平略有升高，但差异无统计学意义（P = 0.13）。在多变量回归中，年龄和二硫键/天然硫醇比值是SO的独立预测因素（OR = 5.71，P = 0.041）。ROC分析显示，二硫键/天然硫醇比值具有中等预测准确性（AUC = 0.684，P = 0.008），截断值> 6.63时特异性为92.86%。SO的老年人表现出氧化还原平衡紊乱，TDH参数改变证明了这一点。二硫键/天然硫醇比值可能是识别SO的有用氧化生物标志物。这些发现突出了氧化应激在SO中的潜在作用，值得进一步研究针对性的抗氧化策略。
