mRNA疫苗中的质粒DNA杂质
pDNA Impurities in mRNA Vaccines.
作者信息
Roncati Luca, Ghaleb Nazha, Ghaleb Joya, Kfoury Karl
机构信息
Department of Life Sciences, Health, and Health Care Professions, School of Medicine and Surgery, Link Campus University, 00165 Rome, Italy.
Department of Clinical Laboratory Sciences, Faculty of Health Sciences, Balamand University, 00100 Tripoli, Lebanon.
出版信息
Microorganisms. 2025 Aug 24;13(9):1975. doi: 10.3390/microorganisms13091975.
Funded during the emergency phase of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, messenger RNA (mRNA) vaccines are single-stranded, 5'-capped mRNAs produced using a cell-free in vitro transcription from the corresponding plasmid DNA (pDNA) templates, encoding the viral spike (S) protein of SARS-CoV-2 [...].
信使核糖核酸（mRNA）疫苗在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的紧急阶段获得资助，是使用无细胞体外转录从相应的质粒DNA（pDNA）模板产生的单链、5'端加帽的mRNA，编码SARS-CoV-2的病毒刺突（S）蛋白[...]。
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