Spence J D, Pesout A B, Melmon K L
Stroke. 1977 Sep-Oct;8(5):589-94. doi: 10.1161/01.str.8.5.589.
Increasing evidence suggests that higher blood velocity, by causing turbulence and high shear rates at the endothelial surfaces of arteries, may be important in the pathogenesis of atherosclerosis. In order to measure the effects of antihypertensive agents on blood velocity, an improved method has been developed for analysis of Doppler ultrasound velocity recordings. The audio signal from a Doppler velocity meter is subjected to spectral analysis; the sonagraph thus obtained is digitized with the use of a magnetic table on-line with a calculator. Four monkeys were maintained at a hypertensive baseline for six weeks by infusion of angiotensin and isoproterenol. The effects on blood velocity of 72-hour infusions of propranolol, clonidine, hydralazine, and methyldopa were studied. In doses that reduced diastolic pressure by 13--28%, propranolol decreased mean blood velocity (mv) by 17%, clonidine decreased mv by 14%, while methyldopa increased mv 12%, and hydralazine increased mv by 52% (p less than .00001). Antihypertensive drugs appear to have different effects on blood velocity; these differences may influence choice of antihypertensive drugs for the prevention of arterial disease.
越来越多的证据表明，较高的血流速度通过在动脉内皮表面引起湍流和高剪切率，可能在动脉粥样硬化的发病机制中起重要作用。为了测量抗高血压药物对血流速度的影响，已开发出一种改进的方法用于分析多普勒超声速度记录。来自多普勒速度计的音频信号进行频谱分析；由此获得的声谱图通过与计算器联机的磁性表格进行数字化处理。通过输注血管紧张素和异丙肾上腺素，使四只猴子维持六周的高血压基线水平。研究了普萘洛尔、可乐定、肼屈嗪和甲基多巴72小时输注对血流速度的影响。在使舒张压降低13% - 28%的剂量下，普萘洛尔使平均血流速度（mv）降低17%，可乐定使mv降低14%，而甲基多巴使mv增加12%，肼屈嗪使mv增加52%（p小于0.00001）。抗高血压药物似乎对血流速度有不同影响；这些差异可能会影响预防动脉疾病的抗高血压药物的选择。
