Park Jayeon, Chae Yeon, Lee Sungjae, Koo Yoonhoi, Kim Hakhyun, Kang Byeong-Teck, Yun Taesik
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Vet Sci. 2025 Sep 18;12(9):908. doi: 10.3390/vetsci12090908.
Reliable prognostic indicators for congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) in dogs are limited. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a prognostic marker in humans, has not been evaluated in veterinary medicine. This study aimed to assess the HALP score's utility for predicting short-term mortality in dogs with CHF due to MMVD. This retrospective study included 54 small-breed dogs. The HALP score was calculated as: hemoglobin (g/L) × albumin (g/L) × lymphocytes (/L)/platelets (/L). Six-, nine-month, and one-year mortality were assessed. The HALP score was significantly higher in survivor groups. Receiver operating characteristic (ROC) analysis showed good predictive accuracy for six- and nine-month mortality (area under the curve > 0.7). A cut-off of 11.13 for six-month mortality yielded 44.44% sensitivity and 94.44% specificity. Kaplan-Meier analysis confirmed that a higher HALP score was associated with significantly longer survival. The HALP score appears to be a valuable, novel prognostic indicator for short-term mortality in dogs with CHF due to MMVD.
犬黏液瘤性二尖瓣疾病（MMVD）继发充血性心力衰竭（CHF）的可靠预后指标有限。血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分作为人类的一种预后标志物，尚未在兽医学中进行评估。本研究旨在评估HALP评分对预测MMVD所致CHF犬短期死亡率的效用。这项回顾性研究纳入了54只小型犬。HALP评分计算如下：血红蛋白（g/L）×白蛋白（g/L）×淋巴细胞（/L）/血小板（/L）。评估了6个月、9个月和1年的死亡率。存活组的HALP评分显著更高。受试者工作特征（ROC）分析显示，对6个月和9个月死亡率具有良好的预测准确性（曲线下面积>0.7）。6个月死亡率的临界值为11.13时，灵敏度为44.44%，特异性为94.44%。Kaplan-Meier分析证实，较高的HALP评分与显著更长的生存期相关。HALP评分似乎是MMVD所致CHF犬短期死亡率的一个有价值的新预后指标。
