Maytin Edward V, Zeitouni Nathalie C, Updyke Abigail, Negrey Jeffrey T, Shen Alan S, Heusinkveld Lauren E, Anand Sanjay, Warren Christine B, Hasan Tayyaba, Pogue Brian W
Cleveland Clinic, Department of Dermatology, Cleveland, Ohio, United States.
Cleveland Clinic, Department of Biomedical Engineering, Cleveland, Ohio, United States.
J Biomed Opt. 2025 Dec;30(Suppl 3):S34107. doi: 10.1117/1.JBO.30.S3.S34107. Epub 2025 Sep 25.
Noninvasive imaging to accurately measure subtle changes in tumor size is underutilized when assessing therapeutic responses in the skin. During photodynamic therapy (PDT) for basal cell carcinoma (BCC), a better definition of the tumor size threshold for PDT responsiveness is needed.
We aim to quantitatively demonstrate the first clinical evidence of tumor shrinkage after multiple rounds of PDT using a robust measurement and analysis approach.
Tumors were monitored experimentally using a 3D camera and software system (stereo photogrammetry). A total of 122 BCC tumors in 35 patients were treated with PDT (5-ALA and blue light) in three sessions. Calculated volumes and heights were used to plot changes in tumor size.
In total, 70% of BCC cleared completely. Measured heights correlated with histological tumor depth; average heights were to 20% of actual tumor depth. From photogrammetry at baseline, an average height of was found to predict a complete therapeutic response. Thus, our 3D morphometric technique provides a surrogate measure of BCC tumor depth that predicts PDT response and is accurate to well below the millimeter level.
3D photogrammetry can inform the selection of BCC tumors for PDT with exceptionally high spatial accuracy, dramatically better than can be quantified by a clinician.
在评估皮肤治疗反应时，用于准确测量肿瘤大小细微变化的非侵入性成像方法未得到充分利用。在基底细胞癌（BCC）的光动力疗法（PDT）中，需要更好地定义PDT反应性的肿瘤大小阈值。
我们旨在使用强大的测量和分析方法，定量展示多轮PDT后肿瘤缩小的首个临床证据。
使用3D相机和软件系统（立体摄影测量法）对肿瘤进行实验监测。35例患者的122个BCC肿瘤分三个疗程接受了PDT（5-氨基乙酰丙酸和蓝光）治疗。计算得出的体积和高度用于绘制肿瘤大小的变化。
总体而言，70%的BCC完全清除。测量的高度与组织学肿瘤深度相关；平均高度为实际肿瘤深度的20%。从基线时的摄影测量法来看，平均高度为可预测完全治疗反应。因此，我们的3D形态测量技术提供了一种BCC肿瘤深度的替代测量方法，可预测PDT反应，且精确到远低于毫米水平。
3D摄影测量法能够以极高的空间精度为PDT选择BCC肿瘤提供依据，比临床医生的量化方法要好得多。
