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在私立诊所环境中对 MEMOTIN® 治疗耳鸣的真实世界多中心评估:M.E.S.T 研究。

Real-World Multicenter Evaluation of MEMOTIN® for Tinnitus in Private Clinic Settings: The M.E.S.T Study.

作者信息

Kalentakis Zacharias, Economou Vasiliki, Maragkoudakis Pavlos

机构信息

Otolaryngology - Head and Neck Surgery, Sismanoglio General Hospital of Attiki, Athens, GRC.

Biostatistics, Private Statistic Services, Athens, GRC.

出版信息

Cureus. 2025 Aug 27;17(8):e91132. doi: 10.7759/cureus.91132. eCollection 2025 Aug.

DOI:10.7759/cureus.91132
PMID:41018294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12470554/
Abstract

There is currently no universally effective treatment for subjective tinnitus, and management strategies focus on the relief of symptoms rather than a definite cure. In line with this, our prospective, non-interventional, non-placebo-controlled, multicenter clinical study, conducted in private clinics, evaluates the efficacy of taking a daily supplement based on active compounds in alleviating tinnitus-related disability. The study was conducted in adults with tinnitus who were instructed to take one capsule daily, 30 minutes before bedtime, for a duration of three months between March 30 and December 20, 2024. This study aims to provide valuable clinical insights into the potential therapeutic benefits of a dietary supplement in alleviating the symptoms of tinnitus and improving patients' quality of life. Employing validated assessment tools, such as the Tinnitus Handicap Inventory (THI), this study seeks to provide objective evidence regarding the potential benefits of MEMOTIN® as a supportive intervention for individuals suffering from tinnitus.

摘要

目前,对于主观性耳鸣尚无普遍有效的治疗方法,治疗策略侧重于缓解症状而非彻底治愈。与此一致的是,我们在私人诊所进行的前瞻性、非干预性、非安慰剂对照的多中心临床研究,评估了服用基于活性成分的每日补充剂在减轻耳鸣相关残疾方面的疗效。该研究针对患有耳鸣的成年人开展,他们被要求在2024年3月30日至12月20日期间,每天睡前30分钟服用一粒胶囊,持续三个月。本研究旨在为膳食补充剂在减轻耳鸣症状和改善患者生活质量方面的潜在治疗益处提供有价值的临床见解。通过使用经过验证的评估工具,如耳鸣残疾评定量表(THI),本研究旨在提供客观证据,证明MEMOTIN®作为对耳鸣患者的支持性干预措施的潜在益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/12470554/669a2969da48/cureus-0017-00000091132-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/12470554/669a2969da48/cureus-0017-00000091132-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/12470554/669a2969da48/cureus-0017-00000091132-i01.jpg

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本文引用的文献

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Performing a Multicenter Retrospective Study.开展一项多中心回顾性研究。
Hosp Pediatr. 2025 Feb 1;15(2):e77-e82. doi: 10.1542/hpeds.2024-008020.
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The Efficacy of a Food Supplement in the Treatment of Tinnitus with Comorbid Headache: A Statistical and Machine Learning Analysis with a Literature Review.一种食品补充剂治疗合并头痛的耳鸣的疗效:一项结合文献综述的统计与机器学习分析
Audiol Neurootol. 2025;30(2):164-175. doi: 10.1159/000541842. Epub 2024 Oct 18.
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Comparison of Tinnitus Handicap Inventory and Tinnitus Functional Index as Treatment Outcomes.
耳鸣障碍量表与耳鸣功能指数作为治疗结果的比较
Audiol Res. 2022 Dec 26;13(1):23-31. doi: 10.3390/audiolres13010003.
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The Tinnitus Handicap Inventory is a better indicator of the overall status of patients with tinnitus than the Numerical Rating Scale.与数字评定量表相比,耳鸣障碍量表能更好地反映耳鸣患者的整体状况。
Am J Otolaryngol. 2023 Mar-Apr;44(2):103719. doi: 10.1016/j.amjoto.2022.103719. Epub 2022 Dec 2.
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Ginkgo biloba for tinnitus.银杏叶治疗耳鸣。
Cochrane Database Syst Rev. 2022 Nov 16;11(11):CD013514. doi: 10.1002/14651858.CD013514.pub2.
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Associations between sleep disorders and anxiety in patients with tinnitus: A cross-sectional study.耳鸣患者睡眠障碍与焦虑之间的关联:一项横断面研究。
Front Psychol. 2022 Aug 5;13:963148. doi: 10.3389/fpsyg.2022.963148. eCollection 2022.
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Chronic Tinnitus.慢性耳鸣。
Dtsch Arztebl Int. 2022 Apr 1;119(13):219-225. doi: 10.3238/arztebl.m2022.0135.
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Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study.Tinnitan Duo® 治疗伴有情绪困扰的主观性耳鸣的疗效:一项前瞻性、干预性研究。
J Diet Suppl. 2023;20(1):1-14. doi: 10.1080/19390211.2021.1944947. Epub 2021 Jul 5.
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Validation of the Greek Version of Tinnitus Handicap Inventory.耳鸣障碍量表希腊语版本的验证
Audiol Res. 2020 Oct 6;10(2):39-48. doi: 10.4081/audiores.2020.244.
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Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life: A Randomized Clinical Trial.耳鸣再训练疗法与常规护理对耳鸣相关生活质量的影响:一项随机临床试验。
JAMA Otolaryngol Head Neck Surg. 2019 Jul 1;145(7):597-608. doi: 10.1001/jamaoto.2019.0821.