美国北部平原患哮喘的印第安儿童呼吸道合胞病毒特异性IgG浓度的季节性变化。

Seasonal variation in respiratory syncytial virus-specific IgG concentrations in Northern Plains American Indian children with asthma.

作者信息

Erdei Esther, Torgerson Dara, O'Leary Rae, Spear Melissa, Oxendine Jake, Shedden Matias, O'Leary Marcia, Enright Kendra, Best Lyle G

机构信息

University of New Mexico Health Sciences Center College of Pharmacy, Albuquerque, NM.

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif.

出版信息

J Allergy Clin Immunol Glob. 2025 Aug 21;4(4):100560. doi: 10.1016/j.jacig.2025.100560. eCollection 2025 Nov.

DOI:10.1016/j.jacig.2025.100560

PMID:41018685

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12465034/

Abstract

BACKGROUND

Exposure to respiratory syncytial virus (RSV) during childhood is nearly ubiquitous by age 2 years, and infants who develop severe RSV bronchiolitis are more likely to develop asthma later in life.

OBJECTIVE

We sought to quantify IgG response to RSV infection in American Indian children with and without asthma and to investigate the environmental, clinical, and genetic factors that associate with varying response.

METHODS

We compared immunologic response to previous RSV infection in 319 children with and without asthma from a Northern Plains American Indian community and investigated the role of environmental and genetic factors in levels of RSV-specific IgG.

RESULTS

Overall, we found 73% of children to have high concentrations of RSV-specific IgG (>40 IU/mL), which was associated with the absence of asthma ( = 2.6 × 10). Parents of children with asthma reported a higher clinical burden of RSV as compared with those of children without asthma, including previous diagnosis by a health care professional (35% vs 16%; = 3.5 × 10) and previous hospitalization due to RSV (18% vs 7%; = 2.9 × 10). Among RSV-exposed individuals, children with asthma had lower concentrations of RSV IgG as compared with those without asthma (mean, 117 vs 154 IU/mL; = 7.1 × 10). However, this difference was unique to children recruited during the winter months when RSV is thought to circulate more broadly. Multivariate regression confirmed that the strongest predictor of RSV-specific IgG concentration was an asthma and RSV season interaction ( = 8.3 × 10). Among candidate genes, we identified a genetic association between an intronic variant in and RSV-specific IgG concentration whereby the minor allele (A) was associated with higher concentration (rs12979860; = 4.3 × 10).

CONCLUSIONS

Our findings suggest a seasonal difference in immunologic response to RSV infection that varies by asthma status and warrants further investigation.

摘要

背景

到2岁时，儿童期几乎普遍暴露于呼吸道合胞病毒（RSV），患严重RSV细支气管炎的婴儿日后患哮喘的可能性更大。

目的

我们试图量化有或无哮喘的美国印第安儿童对RSV感染的IgG反应，并调查与不同反应相关的环境、临床和遗传因素。

方法

我们比较了来自美国北部平原印第安社区的319名有或无哮喘儿童对既往RSV感染的免疫反应，并调查了环境和遗传因素在RSV特异性IgG水平中的作用。

结果

总体而言，我们发现73%的儿童RSV特异性IgG浓度较高（>40 IU/mL），这与无哮喘相关（P = 2.6×10⁻⁶）。与无哮喘儿童的父母相比，哮喘儿童的父母报告RSV的临床负担更高，包括先前由医护人员诊断（35%对16%；P = 3.5×10⁻⁴）以及先前因RSV住院（18%对7%；P = 2.9×10⁻³）。在暴露于RSV的个体中，与无哮喘儿童相比，哮喘儿童的RSV IgG浓度较低（平均，117对154 IU/mL；P = 7.1×10⁻⁶）。然而，这种差异仅在冬季招募的儿童中存在，此时RSV被认为传播更广泛。多变量回归证实，RSV特异性IgG浓度的最强预测因素是哮喘与RSV季节的相互作用（P = 8.3×10⁻⁶）。在候选基因中，我们确定了TLR4内含子变异与RSV特异性IgG浓度之间的遗传关联，其中次要等位基因（A）与较高浓度相关（rs12979860；P = 4.3×10⁻³）。