物种特异性组织抗原。
Species-specific tissue antigens.
作者信息
Bonstein H S, Rose N R
出版信息
Clin Exp Immunol. 1971 Feb;8(2):291-303.
Rabbit antisera to human tracheal mucosa, liver and gastric mucosa, after complete absorption with human serum, reacted with extracts of all human tissues tested. Monkey tissue extracts also reacted, but tissues of other species did not. The reactions were attributed to `species-specific tissue antigens'. Two of the most prominent antigens were partially isolated and characterized by chromatography, gel filtration, and electrophoresis. Antigen I migrated as β-globulin, Antigen E as a β-globulin. The antigens persisted in malignant and in long-term cultured cells.
用人类血清完全吸收后，兔抗人气管黏膜、肝脏和胃黏膜抗血清与所有测试的人体组织提取物发生反应。猴组织提取物也有反应，但其他物种的组织没有反应。这些反应归因于“物种特异性组织抗原”。通过色谱法、凝胶过滤和电泳对两种最突出的抗原进行了部分分离和表征。抗原I迁移为β球蛋白，抗原E也为β球蛋白。这些抗原在恶性细胞和长期培养的细胞中持续存在。
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