正常和恶性人体组织中的气管特异性抗原。
Trachea-specific antigens in normal and malignant human tissues.
作者信息
Rose N R, Bonstein H S
出版信息
Clin Exp Immunol. 1970 Sep;7(3):355-64.
One to four trachea-specific antigens were demonstrated regularly by means of various rabbit antisera to human tracheal mucosa, using immunoelectrophoresis or Ouchterlony tests. In addition, one or more antigens common to trachea and oesophagus were found. Trachea-specific antisera cross-reacted with rhesus monkey but not with bovine, ovine, equine or porcine trachea. The three most prominent trachea-specific antigens were localized in the same fraction by chromatography. The chromatographic fraction was usable in tanned cell haemagglutination, but only trachea-oesophagus antigen, and not trachea-specific antigen, seemed to attach to tanned cells. Of the ten cancers of the respiratory tract tested, three were found to retain some trachea-specific antigen.
利用免疫电泳或双向琼脂扩散试验，通过各种针对人气管黏膜的兔抗血清，可定期检测到一至四种气管特异性抗原。此外，还发现了气管和食管共有的一种或多种抗原。气管特异性抗血清与恒河猴气管发生交叉反应，但与牛、羊、马或猪的气管不发生交叉反应。通过色谱法将三种最显著的气管特异性抗原定位在同一组分中。该色谱组分可用于鞣酸细胞血凝试验，但似乎只有气管 - 食管抗原，而非气管特异性抗原，能附着于鞣酸细胞。在所检测的十例呼吸道癌症中，发现三例保留了一些气管特异性抗原。
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