大鼠皮内注射前列腺素E和F之间的相互作用。
Interaction between prostaglandins E and F given intradermally in the rat.
作者信息
Crunkhorn P, Willis A L
出版信息
Br J Pharmacol. 1971 Mar;41(3):507-12. doi: 10.1111/j.1476-5381.1971.tb08048.x.
Abstract
- Increases in permeability observed after intradermal injection of prostaglandins PGE(1) or PGE(2) (0.1 mug) into rats were greatly reduced when they were given in admixture with PGF(2alpha). This effect was not seen with PGF(1alpha) at doses of 0.5-1 mug.2. Effects of the histamine releasing agent compound 48/80 (25 ng) were inhibited by PGF(2alpha) (0.5 mug) but not by PGF(1alpha) (0.5 mug).3. Responses to histamine (1 mug), 5-hydroxytryptamine (0.1 mug) and bradykinin (1 mug), which have a direct action on the microvasculature, were not significantly altered by PGF(2alpha) (0.5 mug).4. It is concluded that PGF(2alpha) probably acts by interfering with the release of mast cell histamine by PGE(1), PGE(2) and compound 48/80.
摘要
给大鼠皮内注射前列腺素PGE(1)或PGE(2)（0.1微克）后观察到的通透性增加，在与PGF(2α)混合给药时会大大降低。在0.5 - 1微克剂量的PGF(1α)时未观察到这种效应。
组胺释放剂化合物48/80（25纳克）的作用被PGF(2α)（0.5微克）抑制，但未被PGF(1α)（0.5微克）抑制。
对组胺（1微克）、5 - 羟色胺（0.1微克）和缓激肽（1微克）的反应，这些对微脉管系统有直接作用，未被PGF(2α)（0.5微克）显著改变。
得出的结论是，PGF(2α)可能通过干扰PGE(1)、PGE(2)和化合物48/80释放肥大细胞组胺而发挥作用。
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