前列腺素、激肽与大鼠炎症
Prostaglandins, kinin and inflammation in the rat.
作者信息
Thomas G, West G B
出版信息
Br J Pharmacol. 1974 Feb;50(2):231-5. doi: 10.1111/j.1476-5381.1974.tb08566.x.
Abstract
1 Prostaglandin E(1) and bradykinin exert synergistic effects on vascular permeability in rat skin and in rat paws. Prostaglandin E(2) is inactive in this respect.2 Prostaglandin F(2alpha) reduces the bradykinin response in rat skin but not in rat paws. It also markedly reduces the response of the skin to dextran, 5-hydroxytryptamine and histamine.3 Prostaglandin E(1) and dextran exert synergistic effects in rat skin when threshold doses of each agent are used.4 Rats genetically resistant to dextran fail to respond to intradermal dextran in the presence of prostaglandin E(1).
摘要
前列腺素E(1)和缓激肽对大鼠皮肤和大鼠爪的血管通透性有协同作用。前列腺素E(2)在这方面无活性。
前列腺素F(2α)可降低大鼠皮肤而非大鼠爪对缓激肽的反应。它还能显著降低皮肤对右旋糖酐、5-羟色胺和组胺的反应。
当使用每种药物的阈剂量时，前列腺素E(1)和右旋糖酐在大鼠皮肤中产生协同作用。
对右旋糖酐具有遗传抗性的大鼠在存在前列腺素E(1)的情况下对皮内注射右旋糖酐无反应。
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Prostaglandins, kinin and inflammation in the rat.前列腺素、激肽与大鼠炎症
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本文引用的文献
1
Rats resistant to the dextran anaphylactoid reaction.对右旋糖酐类过敏反应有抗性的大鼠。
Br J Pharmacol Chemother. 1963 Jun;20(3):550-62. doi: 10.1111/j.1476-5381.1963.tb01492.x.
2
Bradykinin and oedema formation in heated paws of rats.大鼠受热爪子中的缓激肽与水肿形成
Br J Pharmacol Chemother. 1967 Sep;31(1):178-87. doi: 10.1111/j.1476-5381.1967.tb01988.x.
3
Skin reactions to prostaglandins.
J Pharm Pharmacol. 1972 May;24(5):407-8. doi: 10.1111/j.2042-7158.1972.tb09017.x.
4
A simple method for the quantitative extraction of dye extravasated into the skin.一种用于定量提取渗入皮肤的染料的简单方法。
J Pharm Pharmacol. 1971 Mar;23(3):218-9. doi: 10.1111/j.2042-7158.1971.tb08647.x.
5
Cutaneous reactions to intradermal prostaglandins.皮内注射前列腺素后的皮肤反应。
Br J Pharmacol. 1971 Jan;41(1):49-56. doi: 10.1111/j.1476-5381.1971.tb09934.x.
6
Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion.通过级联超融合对大鼠炎性渗出物中前列腺素样活性进行平行测定。
J Pharm Pharmacol. 1969 Feb;21(2):126-8. doi: 10.1111/j.2042-7158.1969.tb08213.x.
7
8
Letter: Prostaglandins as regulators of bradykinin responses.
J Pharm Pharmacol. 1973 Sep;25(9):747-8. doi: 10.1111/j.2042-7158.1973.tb10059.x.
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