Baby Miranda, Priya Vijayan, Pallavi Janardhan, Karthik Chand Basude, Srinivasan Laxmikarthika V, Rana Sandeep Singh, Tawil Samah, Haque Shafiul, Ghosh Payel, Bhattacharya Pratik, Khan Mohd Owais, Perwez Syed Khalid, Ahmad Faraz
Department of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, 632014, India.
Center for Innovation in Molecular and Pharmaceutical Sciences (CIMPS), Dr. Reddy's Institute of Life Sciences, Hyderabad, 500046, India.
Int J Womens Health. 2025 Sep 24;17:3201-3228. doi: 10.2147/IJWH.S511297. eCollection 2025.
Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that persists into late adolescence and even adulthood. While a lot of research has addressed the issues of childhood ADHD, manifestation of the condition in adults, particularly females, remains largely obscure. The aim of the present narrative review is to address the sex-specific subtleties of ADHD in adolescent and adult female populations and critically analyze the various intricately complex facets of the associated comorbidities and outcomes, based upon data extracted from scholarly works indexed in online databases (eg, PubMed, Google Scholar, etc). We provide evidences refuting the presumption that ADHD primarily affects men, highlighting the complexity of clinical outcomes and comorbidities, and the consequent misdiagnosis of women as a possible reason. Comprehensive critical assessment of the multiple aspects of psycho-socio-behavioral, cognitive, and other clinical outcomes and comorbidities associated with ADHD in women indicated widespread dysfunctions and atypical characteristics. Furthermore, we also propose the probable utilities of art-based and other unconventional behavioral therapeutic regimens as alternatives and/or additives for the therapy of female ADHD cases to address case- and gender-specific needs and induce an overall improvement in their functioning. While this is not an exhaustive review of the literature, we hope that our points of discussion will generate further interest among scientists, clinicians, and caregivers to address the age and gender specificity of the condition to advance our perspectives of the condition and eventually establish novel therapeutic measures for the same.
注意缺陷多动障碍(ADHD)是一种普遍存在的神经发育障碍,可持续到青春期后期甚至成年期。虽然许多研究已经探讨了儿童ADHD的问题,但该疾病在成年人,尤其是女性中的表现仍然很大程度上不明确。本叙述性综述的目的是探讨青少年和成年女性人群中ADHD的性别特异性细微差别,并根据从在线数据库(如PubMed、谷歌学术等)中索引的学术著作中提取的数据,批判性地分析相关合并症和结局的各种错综复杂的方面。我们提供证据反驳ADHD主要影响男性的假设,强调临床结局和合并症的复杂性,以及女性因此可能被误诊的情况。对与女性ADHD相关的心理社会行为、认知和其他临床结局及合并症的多个方面进行全面的批判性评估,表明存在广泛的功能障碍和非典型特征。此外,我们还提出基于艺术和其他非常规行为治疗方案可能作为女性ADHD病例治疗的替代方法和/或补充方法,以满足病例和性别的特定需求,并促进其功能的全面改善。虽然这不是对文献的详尽综述,但我们希望我们的讨论要点将引起科学家、临床医生和护理人员的进一步兴趣,以解决该疾病的年龄和性别特异性问题,从而推进我们对该疾病的认识,并最终为其建立新的治疗措施。