分离出的人脑动脉对生物胺的反应性。

Reactivity of isolated human cerebral arteries to biogenic amines.

作者信息

Shibata S, Cheng J B, Murakami W

出版信息

Blood Vessels. 1977;14(6):356-65. doi: 10.1159/000158143.

Abstract

Serotonin (5-HT), histamine, norepinephrine, methoxamine and isoproterenol caused dose-dependent contraction of human cerebral arteries. The potency of 5-HT was greater among test agents in the basilar arteries, whereas it was equivalent to that of norepinephrine in human anterior, middle and posterior cerebral arteries. Acetylcholine and carbachol (10(-9)-10(-5) M) caused a negligible response in human cerebral arteries. Contractile response to 5-HT was greater in the distal rather than middle portion of the human basilar arteries while this order was reversed in the response to norepinephrine. Tyramine (10(-4) M) caused tonic contraction and nicotine (10(-4) M) and electrical transmural stimulation produced phasic contraction of arteries which were antagonized by adrenergic blocking agents. Adenine nucleotides failed to cause relaxation and only high concentration of adenosine caused a minute relaxation. However, papaverine and nitroglycerin caused marked relaxation. These results suggest that adrenergic mechanism may play a role in the regulation of vascular tone in human cerebral arteries.

摘要

血清素（5-羟色胺，5-HT）、组胺、去甲肾上腺素、甲氧明和异丙肾上腺素可引起人脑动脉的剂量依赖性收缩。在受试药物中，5-HT对基底动脉的作用更强，而在大脑前、中、后动脉中，其作用与去甲肾上腺素相当。乙酰胆碱和卡巴胆碱（10⁻⁹ - 10⁻⁵ M）在人脑动脉中引起的反应可忽略不计。人基底动脉远端对5-HT的收缩反应大于中部，而去甲肾上腺素的反应顺序则相反。酪胺（10⁻⁴ M）引起强直性收缩，尼古丁（10⁻⁴ M）和经壁电刺激引起动脉的相位性收缩，这些反应可被肾上腺素能阻断剂拮抗。腺嘌呤核苷酸未能引起舒张，只有高浓度的腺苷引起轻微舒张。然而，罂粟碱和硝酸甘油引起明显舒张。这些结果表明，肾上腺素能机制可能在人脑血管张力调节中起作用。