Marvola M, Reinikainen A, Heliövaara M L, Huikari A
J Pharm Pharmacol. 1979 Sep;31(9):615-8. doi: 10.1111/j.2042-7158.1979.tb13603.x.
The effects of some sugars and osmotic pressure have been examined on the absorption of sulfafurazole in the rat. Statistically significant correlations were found among the hypertonic solutions between the reciprocal of osmotic pressure and AUC0--infinity or Cmax. In addition, negative correlation existed between plasma concentrations at 15 min and osmotic pressure. No significant correlations were noted among the hypotonic solutions. More attention should be paid to the osmotic pressure of formulations. The osmotic pressure of hypertonic solutions, especially, might affect absorption of drug from its dosage form.
已经研究了某些糖类和渗透压对大鼠体内磺胺异恶唑吸收的影响。在高渗溶液中，发现渗透压的倒数与AUC0-∞或Cmax之间存在统计学上的显著相关性。此外，15分钟时的血浆浓度与渗透压之间存在负相关。在低渗溶液中未观察到显著相关性。应更加关注制剂的渗透压。特别是高渗溶液的渗透压可能会影响药物从其剂型中的吸收。
