Pittillo R F, Woolley C, Rice L S
Appl Microbiol. 1971 Oct;22(4):564-6. doi: 10.1128/am.22.4.564-566.1971.
A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of Escherichia coli which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33 ld(10), injected intraperitoneally.
针对博来霉素开发了一种微生物学检测方法，博来霉素是一种据报道在人体试验中有活性的抗肿瘤抗生素。检测用细菌是一株对乙硫氨酸耐药的大肠杆菌。研究表明，腹腔注射单剂量<0.33 ld(10)的博来霉素后，小鼠血液和尿液中的博来霉素浓度相对较高。
