博来霉素，一种抗肿瘤抗生素：正常小鼠中微生物测定及组织分布研究的改进
Bleomycin, and antitumor antibiotic: improved microbiological assay and tissue distribution studies in normal mice.
作者信息
Pittillo R F, Woolley C, Rice L S
出版信息
Appl Microbiol. 1971 Oct;22(4):564-6. doi: 10.1128/am.22.4.564-566.1971.
Abstract
A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of Escherichia coli which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33 ld(10), injected intraperitoneally.
摘要
针对博来霉素开发了一种微生物学检测方法，博来霉素是一种据报道在人体试验中有活性的抗肿瘤抗生素。检测用细菌是一株对乙硫氨酸耐药的大肠杆菌。研究表明，腹腔注射单剂量<0.33 ld(10)的博来霉素后，小鼠血液和尿液中的博来霉素浓度相对较高。
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本文引用的文献
1
Biological studies on bleomycin A.
J Antibiot (Tokyo). 1967 Jul;20(3):149-55.
2
Activity and toxicity of bleomycin.
J Antibiot (Tokyo). 1967 Jan;20(1):15-24.
3
Purification of bleomycins.
J Antibiot (Tokyo). 1966 Sep;19(5):210-5.
4
New antibiotics, bleomycin A and B.
J Antibiot (Tokyo). 1966 Sep;19(5):200-9.
5
Biological studies on individual bleomycins.
J Antibiot (Tokyo). 1968 Oct;21(10):592-602. doi: 10.7164/antibiotics.21.592.
6
Effects of bleomycin on transplantable mouse tumors.
J Antibiot (Tokyo). 1968 Nov;21(11):631-7. doi: 10.7164/antibiotics.21.631.
7
Determination of certain antitumor agents in mouse blood by microbiologic assay.
Cancer Res. 1968 Jun;28(6):1095-109.
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