放线菌素A3，一种抗肿瘤抗生素：通过微生物测定法对小鼠进行的组织分布研究。
Chromomycin A 3 , an antitumor antibiotic: tissue distribution studies in mice as measured by microbial assay.
作者信息
Pittillo R F, Woolley C
出版信息
Appl Microbiol. 1971 Sep;22(3):300-2. doi: 10.1128/am.22.3.300-302.1971.
Abstract
A microbiological assay has been developed for chromomycin A(3), an antitumor antibiotic showing promise in human trials. The assay bacterium is a derived strain of Streptococcus faecalis resistant to methotrexate. Studies with mice revealed that relatively high concentrations of this antibiotic were maintained in the blood, kidneys, and liver of mice after a single-dose intraperitoneal injection of the drug.
摘要
已开发出一种用于色霉素A（3）的微生物测定法，色霉素A（3）是一种在人体试验中显示出前景的抗肿瘤抗生素。测定用细菌是对甲氨蝶呤耐药的粪链球菌衍生菌株。对小鼠的研究表明，单次腹腔注射该药物后，小鼠的血液、肾脏和肝脏中能维持相对较高浓度的这种抗生素。
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本文引用的文献
1
Clinical experience with a new antitumor agent chromomycin.新型抗肿瘤药物放线菌素的临床经验。
Cancer Chemother Rep. 1961 Jul;13:91-7.
2
Further observations on the inhibiting effects of chromomycin A3 on transplantable tumors.关于放线菌素A3对可移植肿瘤抑制作用的进一步观察
Cancer Chemother Rep. 1961 Jul;13:99-106.
3
Olivomycin, mithramycin, chromomycin: three related cancerostatic antibiotics.橄榄霉素、光神霉素、色霉素：三种相关的抗癌抗生素。
Adv Chemother. 1965;2:179-95. doi: 10.1016/b978-1-4831-9930-6.50009-5.
4
Cytosine arabinoside sensitivity in actinobolin-resistant Streptococcus faecalis: the basis of a utilitarian microbiological assay.对放线菌素抗性粪肠球菌中阿糖胞苷敏感性：一种实用微生物学检测方法的基础
Proc Soc Exp Biol Med. 1967 Feb;124(2):636-40. doi: 10.3181/00379727-124-31811.
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