Sadrinasab Shayan, Aminiyan Armin, Saket Sadaf, Khosravi Fatemeh, Pourmohammadi Nadia, Saadat Fakhr Masoud
Shahid Beheshti University, Tehran, Iran.
Islamic Azad University System, Tehran, Iran.
Front Neurol. 2025 Oct 1;16:1553018. doi: 10.3389/fneur.2025.1553018. eCollection 2025.
Achieving maximal safe resection during glioma surgery while preserving neurological function remains a significant challenge. Intraoperative ultrasound (IOUS) offers real-time imaging that dynamically adapts to brain shift and surgical progression. This review highlights recent advances in IOUS, including established modalities such as contrast-enhanced and 3D ultrasound, and emerging innovations such as functional ultrasound (FUS), 4D volumetric imaging, artificial intelligence (AI)-assisted interpretation, and ultrasound-sensitive nanobubbles. These technologies aim to improve the identification of residual tumor, delineate infiltrative margins, and enable functional preservation. Integration with neuronavigation systems enhances accuracy, while new theranostic strategies suggest a future role for ultrasound in intraoperative therapy. Collectively, these developments position IOUS as a central component in the evolution of precision glioma surgery.
在保留神经功能的同时，在胶质瘤手术中实现最大程度的安全切除仍然是一项重大挑战。术中超声（IOUS）提供实时成像，可动态适应脑移位和手术进展。本综述重点介绍了术中超声的最新进展，包括已确立的模式，如对比增强超声和三维超声，以及新兴的创新技术，如功能超声（FUS）、四维容积成像、人工智能（AI）辅助解读和超声敏感纳米气泡。这些技术旨在改善残留肿瘤的识别、勾勒浸润边缘并实现功能保留。与神经导航系统集成可提高准确性，而新的诊疗策略表明超声在术中治疗中将发挥未来作用。总体而言，这些进展使术中超声成为精准胶质瘤手术发展的核心组成部分。
