Thomsen Morten B
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Acta Physiol (Oxf). 2025 Nov;241(11):e70116. doi: 10.1111/apha.70116.
Many physiological parameters, such as heart rate and blood pressure, display pronounced daily rhythms, with significant differences between day and night levels. The ability to anticipate the 24 h cycle of ambient light confers an adaptive advantage, allowing organisms to prepare for periods of activity and rest. Considering chronophysiology is essential when designing, conducting, and interpreting laboratory experiments because of the often considerable amplitude of the rhythms. This review introduces a straightforward mathematical tool to detect 24 h rhythms in physiological datasets. Next, the review examines 24-h diurnal rhythms in heart rate, QT interval, and blood pressure, based on telemetry recordings from conscious, freely moving mice. These examples illustrate how long-term, continuous monitoring of physiological parameters enables precise characterization of daily cycles when present. Furthermore, the large datasets obtained through methods such as telemetry make it possible to determine whether the observed rhythms are dependent on heart rate. Circadian and diurnal rhythms play an essential role in cardiovascular physiology, influencing key parameters such as heart rate and blood pressure. Considering chronophysiology is therefore essential when designing, conducting, and interpreting physiological studies.
许多生理参数，如心率和血压，呈现出明显的每日节律，昼夜水平之间存在显著差异。能够预测环境光的24小时周期具有适应性优势，使生物体能够为活动和休息阶段做好准备。由于节律的幅度通常相当大，因此在设计、进行和解释实验室实验时，考虑时间生理学至关重要。本综述介绍了一种简单的数学工具，用于检测生理数据集中的24小时节律。接下来，该综述基于对清醒、自由活动小鼠的遥测记录，研究了心率、QT间期和血压的24小时昼夜节律。这些例子说明了对生理参数进行长期、连续监测如何能够在存在每日周期时精确表征它们。此外，通过遥测等方法获得的大量数据集使得确定观察到的节律是否依赖于心率成为可能。昼夜节律在心血管生理学中起着至关重要的作用，影响着心率和血压等关键参数。因此，在设计、进行和解释生理学研究时，考虑时间生理学至关重要。
