Lepow M L, Goldschneider I, Gold R, Randolph M, Gotschlich E C
Pediatrics. 1977 Nov;60(5):673-80.
Persistence of antibody following immunization with groups A and C meningococcal polysaccharides was studied in two groups of children. Cohort 1 (20 children, 2 to 11 years of age) received two doses of A vaccine three years apart; cohort 2 (1,345 children, 6 to 8 years of age) received A or C vaccine initially and the heterologous vaccine one year later. No significant reactions were observed. Geometric mean anti-A concentrations one month after primary and booster immunization in cohort 1 were 8.77 and 13.08 microgram/ml, respectively. Mean anti-A concentration declined 32% one year after booster immunization, but then stabilized. Mean anti-A and anti-C concentrations in cohort 2 were 9.35 and 9.12 microgram/ml, respectively, one month after primary immunization. Mean anti-A concentration declined to 5.54 and 3.62 microgram/ml while anti-C levels fell to 2.35 and 1.47 microgram/ml one and four years after immunization. The proportion of children in cohort 2 with greater than or equal to 2.0 microgram/ml of anti-A and anti-C four years after immunization were 80% and 40%, respectively. An antibody concentration greater than or equal to 2.0 microgram/ml has been associated with protection against meningococcal disease. The results suggest that routine immunization of young infants with group A vaccine may result in long-lasting immunity. The usefulness of the presently available group C vaccine appears to be limited to the control of epidemics.
在两组儿童中研究了用A群和C群脑膜炎球菌多糖免疫后抗体的持续性。队列1（20名2至11岁儿童）每隔三年接种两剂A疫苗；队列2（1345名6至8岁儿童）最初接种A疫苗或C疫苗，一年后接种异源疫苗。未观察到明显反应。队列1初次免疫和加强免疫后1个月的几何平均抗A浓度分别为8.77和13.08微克/毫升。加强免疫后1年，平均抗A浓度下降32%，但随后趋于稳定。队列2初次免疫后1个月的平均抗A和抗C浓度分别为9.35和9.12微克/毫升。免疫后1年和4年，平均抗A浓度分别降至5.54和3.62微克/毫升，而抗C水平分别降至2.35和1.47微克/毫升。队列2中免疫后4年抗A和抗C浓度大于或等于2.0微克/毫升的儿童比例分别为80%和40%。抗A浓度大于或等于2.0微克/毫升与预防脑膜炎球菌病有关。结果表明，对幼儿常规接种A群疫苗可能会产生持久免疫力。目前可用的C群疫苗的用途似乎仅限于控制疫情。
