Wong M M, Guest M F, Lim K C, Sivanandam S
Southeast Asian J Trop Med Public Health. 1977 Jun;8(2):265-73.
Twenty-eight rhesus monkeys in 3 groups were exposed to single (Group I), double (Group II), and multiple (Group III) inoculations with B. malayi infective larvae. Infections were monitored by microfilarial and blood counts, selected biochemical tests, IFA responses, and records of body temperature and lymphadenopathy before and/or after treatment with DEC. As a whole, the highest microfilaraemia levels were observed in Group II and lowest in Group III monkeys. Eosinophilia was a common occurrence but reached the highest mean levels in Group III. Intermittent fevers and lymph node enlargements were observed in all groups of monkeys and the occurrence of these appeared to be correlated. No definite pattern of antibody production was discernable among groups, but an inverse relationship existed between microfilaraemia and detectable microfilarial antibodies. Treatment with DEC produced a microfilaraemia-taxic effect within the initial half hour and responses to treatment varied according to individuals. Although post-treatment reinfection appeared to cause lymphoid responses and tissue eosinophilia, no substantial resistance to reinfection was observed.
将28只恒河猴分为3组，分别接受马来布鲁线虫感染性幼虫的单次（第一组）、两次（第二组）和多次（第三组）接种。通过微丝蚴计数和血细胞计数、选定的生化检测、免疫荧光分析反应以及在使用乙胺嗪治疗之前和/或之后的体温和淋巴结病记录来监测感染情况。总体而言，第二组猴子的微丝蚴血症水平最高，第三组猴子的最低。嗜酸性粒细胞增多症很常见，但第三组的平均水平最高。在所有组的猴子中均观察到间歇性发热和淋巴结肿大，且这些症状的出现似乎相关。各组之间未发现明确的抗体产生模式，但微丝蚴血症与可检测到的微丝蚴抗体之间存在反比关系。乙胺嗪治疗在最初半小时内产生了微丝蚴血症趋化效应，且个体对治疗的反应各不相同。尽管治疗后再次感染似乎会引起淋巴反应和组织嗜酸性粒细胞增多，但未观察到对再次感染的实质性抵抗力。
