Crockard H A, Clark J, Warnock M L, Churg A M, Hanlon K
Surgery. 1977 Nov;82(5):588-98.
Parameters of cerebral and pulmonary function were studied in ten animals whose brains were perfused with hypoxic right atrial blood according to the Moss method. All animals died as a result of cerebral hypoxia at about 95 minutes after the onset of perfusion. Gross pulmonary congestion, edema, and leukocyte plugs occurred in the seven animals breathing spontaneously, but positive pressure ventilation prevented these changes in three. The resumption of cerebral perfusion with oxygenated blood after 30 minutes of the Moss procedure did not prevent the pulmonary changes and, of more importance, did not prevent cerebral swelling and death at about the same time as that of all the other animals. There were no changes in oxygen uptake or in arterial oxygen tension to indicate that progressive pulmonary failure contributed to death. It is concluded that this model produces brain swelling and brain death with incidental pulmonary pathological changes indistinguishable from early findings in hemorrhagic shock models and that the cerebral hypoxic perfusion model in monkeys is not suitable for studying the effects of "shock lung" therapy.
根据莫斯方法，对10只大脑用缺氧右心房血液灌注的动物的脑和肺功能参数进行了研究。所有动物在灌注开始后约95分钟因脑缺氧死亡。7只自主呼吸的动物出现了严重的肺充血、水肿和白细胞栓子，但3只采用正压通气的动物未出现这些变化。在莫斯手术30分钟后用含氧血液恢复脑灌注并不能预防肺部变化，更重要的是，不能预防脑肿胀和死亡，其时间与所有其他动物大致相同。氧摄取或动脉血氧张力没有变化表明进行性肺衰竭导致死亡。得出的结论是，该模型产生脑肿胀和脑死亡，并伴有与出血性休克模型早期发现难以区分的偶然肺部病理变化，并且猴子的脑缺氧灌注模型不适用于研究“休克肺”疗法的效果。
