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肌腱组织工程：肌腱病的病理生理机制与生物工程治疗

Tendon Tissue Engineering: Pathophysiological Mechanism and Bioengineering Therapy of Tendinopathy.

作者信息

Chen Bin, Zhao Yingqi, Guo Shizhen, Tang Chuyue, Xu Baoyun, Zhou Mei, Chen Qianbo, Ma Lin, Lyu Jingtong, Guo Lin, Wang Yunjiao

机构信息

Department of Orthopeadics/Sports Medicine Center, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China.

Department of Orthopedics, Chongqing Hospital of The Chinese People's Armed Police Force, Chongqing, People's Republic of China.

出版信息

Int J Nanomedicine. 2025 Oct 15;20:12529-12571. doi: 10.2147/IJN.S550439. eCollection 2025.

DOI:10.2147/IJN.S550439
PMID:41127789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12538227/
Abstract

Tendinopathy afflicts many professional athletes and the elderly. However, due to the unique cellular and histological composition of tendons, healing is frequently unsatisfactory. The clinical physical therapy and surgical interventions often fail to meet patient expectations. In recent years, bioengineering technology has undergone rapid development, with a significant number of studies in the biological field focusing on bioengineering technology to explore emerging treatments for diseases. Therefore, bioengineering technology has the potential to become an important part of future tendon healing therapies. The present article will describe the sources of scaffolds, biological factors and bioengineering strategies, with a focus on their current applications in laboratory and clinical contexts.

摘要

肌腱病困扰着许多职业运动员和老年人。然而，由于肌腱独特的细胞和组织学组成，愈合情况常常不尽人意。临床物理治疗和手术干预往往无法满足患者的期望。近年来，生物工程技术发展迅速，生物领域的大量研究聚焦于生物工程技术，以探索疾病的新兴治疗方法。因此，生物工程技术有潜力成为未来肌腱愈合治疗的重要组成部分。本文将描述支架材料的来源、生物因子和生物工程策略，重点介绍它们目前在实验室和临床环境中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/60b86d59fbc6/IJN-20-12529-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/014a41bb0004/IJN-20-12529-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/132656657d5b/IJN-20-12529-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/566aa9502764/IJN-20-12529-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/1e89722f5506/IJN-20-12529-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/219bad9af519/IJN-20-12529-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/867a85bf251e/IJN-20-12529-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/8fd614448b01/IJN-20-12529-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/18ccba604d59/IJN-20-12529-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/60b86d59fbc6/IJN-20-12529-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/014a41bb0004/IJN-20-12529-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/132656657d5b/IJN-20-12529-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/566aa9502764/IJN-20-12529-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/1e89722f5506/IJN-20-12529-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/219bad9af519/IJN-20-12529-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/867a85bf251e/IJN-20-12529-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/8fd614448b01/IJN-20-12529-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/18ccba604d59/IJN-20-12529-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feae/12538227/60b86d59fbc6/IJN-20-12529-g0009.jpg

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本文引用的文献

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Research Progress on the Preparation and Application of Decellularized Tendons.脱细胞肌腱的制备与应用研究进展
Curr Issues Mol Biol. 2025 Apr 6;47(4):251. doi: 10.3390/cimb47040251.
2
Electrospinning and Nanofiber Technology: Fundamentals, Innovations, and Applications.静电纺丝与纳米纤维技术：基础、创新与应用
Adv Mater. 2025 Apr 7:e2500162. doi: 10.1002/adma.202500162.
3
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing.
时空响应级联双层微针整合局部葡萄糖消耗和持续一氧化氮释放以加速糖尿病伤口愈合。
Acta Pharm Sin B. 2024 Nov;14(11):5037-5052. doi: 10.1016/j.apsb.2024.06.014. Epub 2024 Jun 24.
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Coaxial Electrospun Nanofibrous Membranes as Dual-Functional Biomimetic Tendon Sheath for Tendon Repair and Anti-Peritendinous Adhesion.同轴静电纺纳米纤维膜作为用于肌腱修复和抗腱周粘连的双功能仿生腱鞘
Adv Healthc Mater. 2025 Jan;14(1):e2402074. doi: 10.1002/adhm.202402074. Epub 2024 Nov 26.
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3D-printed biomimetic scaffolds loaded with ADSCs and BMP-2 for enhanced rotator cuff repair.负载脂肪干细胞和骨形态发生蛋白-2的3D打印仿生支架用于增强肩袖修复
J Mater Chem B. 2024 Dec 4;12(47):12365-12377. doi: 10.1039/d4tb01073f.
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Developing fibrin-based biomaterials/scaffolds in tissue engineering.在组织工程中开发基于纤维蛋白的生物材料/支架。
Bioact Mater. 2024 Aug 15;40:597-623. doi: 10.1016/j.bioactmat.2024.08.006. eCollection 2024 Oct.
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Growth Differentiation Factor 5-Induced Mesenchymal Stromal Cells Enhance Tendon Healing.生长分化因子 5 诱导的间充质基质细胞增强肌腱愈合。
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