Li Jing, Wen Mingxing, Zhang Sujuan, Du Lingfei, Fan Xin, Liang Hao, Wang Hong, Sun Jing, Ding Yuchun, Ge Liangpeng, Ma Jideng, Zhang Jinwei
Chongqing Academy of Animal Sciences, Chongqing 402460, China.
Sichuan Provincial Key Laboratory of Exploration and Innovative Utilization of Livestock and Poultry Genetic Resources, Sichuan Agricultural University, Chengdu 611130, China.
Curr Issues Mol Biol. 2025 Apr 6;47(4):251. doi: 10.3390/cimb47040251.
Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields of tissue engineering and regenerative medicine in recent years. This paper summarizes the origin, structure, and ECM components of animal tendons, reviews decellularization methods, and discusses recent advancements in the research and applications of decellularized tendons. Furthermore, it explores future development trends of xenogeneic decellularized tendon materials, aiming to provide a reference for fundamental research and the development of biomaterials related to decellularized tendons.
肌腱将动物骨骼与骨骼肌相连，在负重和维持运动功能方面发挥着关键作用。脱细胞后，肌腱细胞外基质（tECM）保留了与天然肌腱相似的物理化学特性。近年来，这使得tECM成为组织工程和再生医学领域中一种有前景的生物材料。本文总结了动物肌腱的起源、结构和细胞外基质成分，综述了脱细胞方法，并讨论了脱细胞肌腱研究与应用的最新进展。此外，还探讨了异种脱细胞肌腱材料的未来发展趋势，旨在为脱细胞肌腱相关的基础研究和生物材料开发提供参考。
