Hooley R D, Fell L R, Findlay J K
Acta Endocrinol (Copenh). 1977 Dec;86(4):722-7. doi: 10.1530/acta.0.0860722.
The effects of two ergot alkaloids, 2-bromo-alpha-ergocryptine methane-sulphonate (CB154, Sandoz) and lergotrile mesylate (LM, E. Lilly & Co.), on the basal secretion of prolactin and on the prolactin response to TRH or the milking stimulus was investigated in the sheep. Both CB154 (c. 0.5 mg/kg) and LM (c. 0.75 mg/kg) markedly reduced basal levels of prolactin and inhibited the TRH-induced prolactin release in ewes in the mid-luteal phase of the oestrous cycle. Both compounds also suppressed basal levels of prolactin in lactating ewes and inhibited the prolactin response to the milking stimulus in lactating ewes.
研究了两种麦角生物碱，即2-溴-α-麦角隐亭甲磺酸盐（CB154，山德士公司）和甲磺酸麦角腈（LM，礼来公司）对绵羊催乳素基础分泌以及催乳素对促甲状腺激素释放激素（TRH）或挤奶刺激反应的影响。CB154（约0.5毫克/千克）和LM（约0.75毫克/千克）均显著降低了发情周期黄体中期母羊催乳素的基础水平，并抑制了TRH诱导的催乳素释放。这两种化合物还抑制了泌乳母羊催乳素的基础水平，并抑制了泌乳母羊对挤奶刺激的催乳素反应。
