Lider Sean, Mandap Chanel, Gill Pavandeep
Island Medical Program, University of British Columbia, Victoria, BC V8W 2Y2, Canada.
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
Dermatopathology (Basel). 2025 Oct 8;12(4):34. doi: 10.3390/dermatopathology12040034.
There are many benign skin neoplasms encountered in dermatopathology practice that can be associated with underlying genetic disorders. Although benign themselves, these lesions can offer insight into the potential for development of internal malignancies in patients with these hereditary syndromes. An astute dermatopathologist will recognize clues that suggest a syndromic association of these lesions, such as the presence of multiple lesions, distinct histologic growth patterns, and the results of ancillary immunohistochemical testing. The dermatopathologist can then guide the referring clinician to obtain additional clinical and family history and, if appropriate, pursue further screening and genetic testing. This review article will provide an overview of the clinical and histologic features associated with select common and uncommon benign skin neoplasms with syndromic associations.
在皮肤病理学实践中会遇到许多良性皮肤肿瘤，它们可能与潜在的遗传疾病相关。尽管这些病变本身是良性的，但它们可以为患有这些遗传性综合征的患者发生内部恶性肿瘤的可能性提供线索。一位敏锐的皮肤病理学家会识别出提示这些病变存在综合征关联的线索，例如多个病变的存在、独特的组织学生长模式以及辅助免疫组织化学检测结果。然后，皮肤病理学家可以指导转诊的临床医生获取更多的临床和家族病史，并在适当的情况下进行进一步的筛查和基因检测。这篇综述文章将概述与选定的具有综合征关联的常见和不常见良性皮肤肿瘤相关的临床和组织学特征。
