University of California Davis Medical Center, Sacramento, California, USA.
Dermatol Ther. 2010 Nov-Dec;23(6):606-42. doi: 10.1111/j.1529-8019.2010.01368.x.
Many inherited skin conditions are associated with underlying malignancies. The astute clinician will be able to recognize many of these cutaneous findings. The identification of these genetic syndromes with cutaneous findings, or genodermatoses, may allow early recognition of internal malignancies and the extension of these patients' life expectancy. Several of these syndromes have established screening and treatment protocols, which should be utilized in the care of affected patients. This article succinctly reviews the dermatologic, clinical, and laboratory findings associated with genodermatoses that have associated internal malignancies. Appropriate treatment and screening recommendations are explored.
许多遗传性皮肤疾病都与潜在的恶性肿瘤有关。有经验的临床医生能够识别出许多这些皮肤表现。这些具有皮肤表现的遗传综合征，或遗传性皮肤病，可能有助于早期识别内部恶性肿瘤，并延长这些患者的预期寿命。其中一些综合征已经建立了筛查和治疗方案，这些方案应在治疗受影响的患者时使用。本文简洁地回顾了与遗传性皮肤病相关的皮肤科、临床和实验室发现，这些疾病都与内部恶性肿瘤有关。探讨了适当的治疗和筛查建议。
