Javed Faraha, Akhter Rahena, Miletic Vesna
Dr. Ziauddin Ahmed Dental College, Aligarh Muslim University, Aligarh, India.
Faculty of Medicine and Health, Sydney Dental School, The University of Sydney, Sydney, Australia.
Lasers Med Sci. 2025 Oct 24;40(1):454. doi: 10.1007/s10103-025-04656-9.
To synthesize evidence from systematic reviews evaluating the effectiveness of laser therapy in the management of dentine hypersensitivity (DH). A comprehensive search was conducted across nine databases-PubMed, Cochrane Library, Medline, Scopus, Embase, Web of Science, DARE, PROSPERO, and ProQuest Dissertations & Theses-from inception to June 2025. This review followed a registered PROSPERO protocol and adhered to JBI and Cochrane methodological standards. Twenty-five systematic reviews were included. Methodological quality and risk of bias were assessed using the JBI checklist and the ROBIS tool. Overlap of primary studies was evaluated using citation matrices and the Corrected Covered Area (CCA) method. Laser therapy, either as a standalone intervention or combined with desensitizing agents, was consistently associated with short-term reduction in DH-related pain. Several high-quality reviews supported its effectiveness over placebo or no treatment. However, results were inconsistent when compared to other desensitizing agents. Only 7 reviews were rated as high quality, and most reviews had a high risk of bias, primarily due to lack of protocol registration, incomplete search strategies, and insufficient reporting of bias assessment. The CCA score of 3.9% indicated slight overlap among primary studies. Laser therapy appears to be effective for short-term relief of dentine hypersensitivity, but current evidence is limited by methodological weaknesses in existing reviews. Standardized clinical trial protocols, long-term follow-up data, and cost-effectiveness studies are essential to inform future clinical and policy decisions.
综合系统评价中的证据，以评估激光疗法在治疗牙本质过敏症（DH）方面的有效性。对九个数据库（PubMed、Cochrane图书馆、Medline、Scopus、Embase、科学网、DARE、PROSPERO以及ProQuest学位论文数据库）进行了全面检索，检索时间从建库至2025年6月。本综述遵循已注册的PROSPERO方案，并遵循JBI和Cochrane的方法学标准。纳入了25项系统评价。使用JBI清单和ROBIS工具评估方法学质量和偏倚风险。使用引文矩阵和校正覆盖面积（CCA）方法评估原始研究的重叠情况。激光疗法，无论是作为单一干预措施还是与脱敏剂联合使用，均与DH相关疼痛的短期减轻始终相关。几项高质量的综述支持其相对于安慰剂或不治疗的有效性。然而，与其他脱敏剂相比，结果并不一致。只有7项综述被评为高质量，且大多数综述存在较高的偏倚风险，主要原因是缺乏方案注册、搜索策略不完整以及偏倚评估报告不充分。CCA评分为3.9%表明原始研究之间存在轻微重叠。激光疗法似乎对牙本质过敏症的短期缓解有效，但现有综述中的方法学缺陷限制了当前证据。标准化的临床试验方案、长期随访数据以及成本效益研究对于为未来的临床和政策决策提供信息至关重要。
