酒精在体外和体内对染色体的损伤。
Chromosomal damage by alcohol in vitro and in vivo.
作者信息
Obe G, Ristow H J, Herha J
出版信息
Adv Exp Med Biol. 1977;85A:47-70. doi: 10.1007/978-1-4899-5181-6_4.
PMID:411347
Abstract
Alcohol has no damaging effects on human chromosomes in vitro. The chromosomes of alcoholics, however, show a significant elevation of aberrations. Alcohol inhibits cellular and cell free RNA synthesis. One possible reason for the mutagenic activity of alcohol in vivo may be an inhibition of cellular repair.
摘要
酒精在体外对人类染色体没有破坏作用。然而，酗酒者的染色体显示出畸变率显著升高。酒精会抑制细胞内和无细胞体系的RNA合成。酒精在体内具有诱变活性的一个可能原因或许是对细胞修复的抑制。
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