Zeng Xiao, Shen Hong, Luo Deyi, Jin Tao
Department of Urology and Institute of Urology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China.
Department of pelvic floor diseases center, West China TianFu Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
BMC Urol. 2025 Oct 24;25(1):265. doi: 10.1186/s12894-025-01957-7.
This study was designed to quantitatively analyze time-related parameters in uroflowmetry curve patterns in patients with benign prostatic hyperplasia and bladder outlet obstruction, and to investigate their potential clinical implications.
A total of 63 patients were included in this retrospective, single-center study. The benign prostatic hyperplasia (BPH) with benign prostatic obstruction(BPO) group consisted of 37 patients, while the nromal group included 26 individuals. Urodynamic study traces and clinical data were analyzed based on inclusion and exclusion criteria. Time-related parameters, including: Time to Qmax (T1), The time from Qmax to the end of uroflow (T2), and Uroflow time (T3 = T1 + T2), as well as corresponding ratios, were quantified and compared between the two groups.
Significant differences were observed in several time-related parameters between the BPH with BPO group and the normal group. There following parameters demonstrated statistically significant differences: T1 [5 (3.25, 7) s vs. 8.5 (6, 11.5) s, p = 0.00], T2 [23 (15, 34.5) s vs. 10 (6.75, 13.25) s, p = 0.00], T3 [30 (20, 40.5) s vs. 19 (14.75, 23.25) s, p = 0.00], T1/T2 [0.20 (0.13, 0.30) vs. 0.89 (0.65, 1.12), p = 0.00], T1/T3 [0.18 ± 0.10 vs. 0.47 ± 0.10, p = 0.00], T2/T3 [0.82 ± 0.10 vs. 0.54 ± 0.09, p = 0.00].The BPH with BOO group exhibited a shorter time to Qmax onset but significantly prolonged overall voiding duration, a pattern that was consistent with the distinctive "comet tail-like" morphology frequently observed in their uroflowmetry curves. Furthermore, several time-related parameters were identified as potential independent risk factors for bladder outlet obstruction index (BOOI).
The time-related parameters in uroflowmetry curve patterns in BPH patients with BPO show distinct characteristics compared to the normal group. These findings suggest that such parameters may serve as valuable diagnostic indicators for bladder outlet obstruction, though further studies with larger sample sizes are needed for confirmation.
本研究旨在定量分析良性前列腺增生和膀胱出口梗阻患者尿流率曲线模式中的时间相关参数，并探讨其潜在的临床意义。
本项回顾性单中心研究共纳入63例患者。良性前列腺增生伴良性前列腺梗阻（BPH-BPO）组37例，正常组26例。根据纳入和排除标准分析尿动力学研究轨迹和临床资料。对两组的时间相关参数进行量化和比较，这些参数包括：达到最大尿流率的时间（T1）、从最大尿流率到尿流结束的时间（T2）以及尿流时间（T3=T1+T2），以及相应的比值。
BPH-BPO组与正常组在几个时间相关参数上存在显著差异。以下参数显示出统计学显著差异：T1[5（3.25，7）秒对8.5（6，11.5）秒，p=0.00]，T2[23（15，34.5）秒对10（6.75，13.25）秒，p=0.00]，T3[30（20，40.5）秒对19（14.75，23.25）秒，p=0.00]，T1/T2[0.20（0.13，0.30）对0.89（0.65，1.12），p=0.00]，T1/T3[0.18±0.10对0.47±0.10，p=0.00]，T2/T3[0.82±0.10对0.54±0.09，p=0.00]。BPH-BOO组达到最大尿流率起始的时间较短，但总体排尿持续时间显著延长，这种模式与他们尿流率曲线中经常观察到的独特“彗星尾样”形态一致。此外，几个时间相关参数被确定为膀胱出口梗阻指数（BOOI）的潜在独立危险因素。
BPH伴BPO患者尿流率曲线模式中的时间相关参数与正常组相比具有明显特征。这些发现表明，这些参数可能作为膀胱出口梗阻的有价值诊断指标，不过需要更大样本量的进一步研究来证实。
