第三方混合淋巴细胞培养试验：一种潜在的组织相容性检测新方法。
Third party mixed-leukocyte culture test: a potential new method of histocompatibility testing.
作者信息
Park B H, Good R A
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1490-3. doi: 10.1073/pnas.69.6.1490.
The disparity index is an expression of histocompatibility difference between two siblings with identical human leukocyte antigen (HL-A) type who are nonreactive in mixed leukocyte culture (MLC) test. This index is derived from a third-party MLC test. The disparity index was found to be correlated with the severity of graft-versus-host reaction in bone marrow transplantation between HL-A-identical siblings. The disparity index may prove to be a useful means of predicting the severity of graft-versus-host reaction and the outcome of bone marrow graft when HL-A- and MLC-matched sibling donors are studied. The third-party MLC test is offered as a new method of histocompatibility testing. It may provide a useful model for the study of immunogenetics relative to so-called weaker histocompatibility determinants in man and experimental animals.
差异指数是指在混合淋巴细胞培养（MLC）试验中无反应的、人类白细胞抗原（HL-A）类型相同的两个同胞之间组织相容性差异的一种表达形式。该指数源自第三方MLC试验。已发现差异指数与HL-A相同的同胞之间骨髓移植中移植物抗宿主反应的严重程度相关。当研究HL-A和MLC匹配的同胞供体时，差异指数可能被证明是预测移植物抗宿主反应严重程度和骨髓移植结果的一种有用方法。第三方MLC试验作为一种新的组织相容性检测方法被提出。它可能为研究人类和实验动物中所谓较弱组织相容性决定簇的免疫遗传学提供一个有用的模型。
Zotero 插件