Schiffman P L, Ashkar B, Bishop M, Cleary M G
Am Rev Respir Dis. 1977 Nov;116(5):821-5. doi: 10.1164/arrd.1977.116.5.821.
Rates of in vitro resistance to antituberculous drugs were examined for all patients hospitalized with active tuberculosis between January 1969 and December 1972, and between March 1975 and September 1976. During the former period, in 31.5 per cent of patients, tuberculosis was resistant to one or more drugs, and in 12.3 per cent of patients was resistant to 2 or more drugs. During the latter period, 35.5 per cent of patients had tuberculosis that was resistant to one or more drugs, and 19.6 per cent had tuberculosis resistant to 2 or more drugs. Resistance to isoniazid and ethambutol increased significantly, whereas resistance to para-aminosalicytic acid decreased. Age, national origin, and length of residence in the United States were not good predictors for the presence of in vitro resistance.
对1969年1月至1972年12月以及1975年3月至1976年9月期间因活动性肺结核住院的所有患者进行了抗结核药物体外耐药率检测。在前一时期，31.5%的患者结核病对一种或多种药物耐药，12.3%的患者对两种或更多药物耐药。在后一时期，35.5%的患者结核病对一种或多种药物耐药，19.6%的患者结核病对两种或更多药物耐药。对异烟肼和乙胺丁醇的耐药性显著增加，而对对氨基水杨酸的耐药性降低。年龄、国籍和在美国的居住时间并不是体外耐药性存在的良好预测指标。
