1968 - 2024年的耳蜗醌：化学、生物合成及生物活性与未来展望

Cochlioquinones 1968-2024: Chemistry, Biosynthesis, and Biological Activities with Future Perspectives.

作者信息

Fang Huiqi, Li Qi, Chen Lin, Ding Gang

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.

Henan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Zhengzhou 450063, China.

出版信息

J Fungi (Basel). 2025 Sep 30;11(10):712. doi: 10.3390/jof11100712.

DOI:10.3390/jof11100712

PMID:41149902

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12565317/

Abstract

Cochlioquinones are a member of meroterpenoids possessing a core 6/6/6/6 tetracyclic ring system, which originate from the polyketide-terpenoid hybrid biosynthesis. Up to date, there are eighty-one analogues with diverse post-modifications isolated from different fungi, most of which exhibit different biological activities, such as phytotoxic, antibacterial, cytotoxic, and immunosuppressive effects. Structurally, cochlioquinones can be mainly categorized into two classes: benzoquinone-type and phenol-type cochlioquinones, respectively. In this review, chemistry and biology of cochlioquinones including the structures, NMR and MS features, bioactivities, and biosynthesis from 1968 to 2024 are systematically summarized, which might provide insights into the exploration and utilization of this group of meroterpenoids in the agricultural or pharmaceutical industry.

摘要

耳蜗醌是具有核心6/6/6/6四环环系的半萜类化合物成员，其起源于聚酮-萜类杂合生物合成。迄今为止，已从不同真菌中分离出81种具有不同后修饰的类似物，其中大多数表现出不同的生物活性，如植物毒性、抗菌、细胞毒性和免疫抑制作用。在结构上，耳蜗醌主要可分为两类：苯醌型和酚型耳蜗醌。在本综述中，系统总结了1968年至2024年耳蜗醌的化学和生物学，包括其结构、核磁共振和质谱特征、生物活性以及生物合成，这可能为该类半萜类化合物在农业或制药行业的开发和利用提供见解。