Bradley W G, Hudgson P, Larson P F, Papapetropoulos T A, Jenkison M
J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):451-5. doi: 10.1136/jnnp.35.4.451.
The finding of a relative absence of degeneration and regeneration in a muscle biopsy taken at 2½ weeks of age from a boy who later showed the florid pathological changes of preclinical Duchenne muscular dystrophy prompted a review of muscle biopsies taken from boys in the preclinical and early clinical stages of this disease. Only one other biopsy obtained in the first year of life was available. In this, taken at 2 months, there were active changes present. These findings suggest that biopsies taken to detect preclinical cases should not be performed at less than 2 months of age, and raise the possibility of the existence of a stage in Duchenne muscular dystrophy before active degeneration when the muscle shows little or no change on light microscopy.
一名男童在2.5周龄时进行了肌肉活检，结果显示相对缺乏变性和再生现象，该男童后来出现了临床前期杜氏肌营养不良症的典型病理变化，这促使人们对处于该疾病临床前期和临床早期的男童的肌肉活检进行回顾。仅有的另一份一岁内获取的活检样本是在2个月时采集的，其中存在活跃性变化。这些发现表明，用于检测临床前期病例的活检不应在2个月龄之前进行，并且增加了杜氏肌营养不良症存在一个阶段的可能性，在该阶段，在光镜下肌肉几乎没有变化，即活跃性变性之前。
