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探索澳大利亚太攀蛇的毒液多样性：[具体毒液成分1]和[具体毒液成分2]的比较特征分析

Exploring the Venom Diversity of Australian Taipans: Comparative Characterization of and .

作者信息

Paz Guilherme Gonelli, Spencer Patrick Jack, Pimenta Daniel Carvalho, Beraldo-Neto Emidio

机构信息

Programa de Pós-Graduação em Ciências-Toxinologia do Instituto Butantan, São Paulo 05503-900, SP, Brazil.

Laboratory of Biochemistry, Instituto Butantan, São Paulo 05503-900, SP, Brazil.

出版信息

Toxins (Basel). 2025 Oct 1;17(10):488. doi: 10.3390/toxins17100488.

DOI:10.3390/toxins17100488
PMID:41150189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12567702/
Abstract

The genus , which includes some of the most venomous snakes in the world, presents a complex venom composition with potent neurotoxic and procoagulant effects. This study provides a comparative proteomic analysis of the venom of (Inland Taipan) and (Coastal Taipan), aiming to elucidate the molecular basis underlying their distinct toxicological profiles. Using high-resolution chromatographic fractionation and LC-MS/MS, we identified a core set of nine protein families shared between both species, including phospholipases A (PLA), three-finger toxins (3FTx), natriuretic peptides (NTP), nerve growth factors (NGF), and prothrombin activators (PTA). venom exhibited greater diversity of 3FTxs and unique protein families, such as Waprin and 5'-nucleotidases, suggesting lineage-specific functional adaptations. Quantitative analysis revealed a greater relative abundance of PLAs in (66%) compared to (47%), whereas 3FTXs were more prominent in (33% vs. 9%). These interspecific differences likely underlie the distinct clinical manifestations of envenomation and reflect evolutionary divergence in the venom composition. Our findings provide molecular insights into taipan venom complexity and highlight novel toxin candidates with potential biomedical applications in neurobiology, hemostasis, and anti-infective therapy.

摘要

该属包含世界上一些毒性最强的蛇类，其毒液成分复杂，具有强大的神经毒性和促凝血作用。本研究对内陆太攀蛇和沿海太攀蛇的毒液进行了比较蛋白质组学分析，旨在阐明它们不同毒理学特征背后的分子基础。通过高分辨率色谱分离和液相色谱-串联质谱法，我们鉴定出两个物种共有的一组核心的九个蛋白质家族，包括磷脂酶A（PLA）、三指毒素（3FTx）、利钠肽（NTP）、神经生长因子（NGF）和凝血酶原激活剂（PTA）。内陆太攀蛇毒液中3FTx和独特蛋白质家族（如Waprin和5'-核苷酸酶）的多样性更高，表明存在谱系特异性功能适应性。定量分析显示，内陆太攀蛇中PLA的相对丰度（66%）高于沿海太攀蛇（47%），而3FTXs在沿海太攀蛇中更为突出（33%对9%）。这些种间差异可能是中毒不同临床表现的基础，并反映了毒液成分的进化分歧。我们的研究结果为太攀蛇毒液的复杂性提供了分子见解，并突出了在神经生物学、止血和抗感染治疗中具有潜在生物医学应用的新型毒素候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/7c60a9e1f4ea/toxins-17-00488-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/32626b0cc574/toxins-17-00488-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/763a93449e36/toxins-17-00488-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/42b5ae81178b/toxins-17-00488-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/443eb766aec1/toxins-17-00488-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/7a83d1edb19f/toxins-17-00488-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/1189624636e4/toxins-17-00488-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cec/12567702/7c60a9e1f4ea/toxins-17-00488-g011.jpg

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本文引用的文献

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