Dal Belo Cháriston André, Hyslop Stephen, Carlini Célia Regina
Departamento Multidisciplinar, Escola Paulista de Política, Economia e Negócios (EPPEN), Universidade Federal de São Paulo (UNIFESP), Rua General Newton Estilac Leal, 932, Quitaúna, Osasco 06190-170, SP, Brazil.
Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Rua Vital Brazil, 80, Cidade Universitária Zeferino Vaz, Campinas 13083-888, SP, Brazil.
Toxins (Basel). 2025 Oct 7;17(10):497. doi: 10.3390/toxins17100497.
Scorpion venoms contain a wide range of toxins that interact with a variety of target molecules (ion channels, receptors and enzymes) associated with synaptic transmission, action potential propagation, cardiac function, hemostasis and other physiological systems. Scorpion toxins are also active towards bacteria, viruses, fungi and parasites. Such interactions make scorpion toxins useful lead molecules for developing compounds with biotechnological and therapeutic applications, and as tools for cell biology. In addition, scorpion toxins act as insectotoxins, with promising applications as insecticides. This review describes the range of scorpion toxins and discusses their usefulness for the development of insecticides and therapeutic drugs.
蝎毒含有多种毒素，这些毒素可与多种与突触传递、动作电位传播、心脏功能、止血及其他生理系统相关的靶分子（离子通道、受体和酶）相互作用。蝎毒对细菌、病毒、真菌和寄生虫也有活性。这些相互作用使蝎毒成为开发具有生物技术和治疗应用化合物的有用先导分子，以及细胞生物学的工具。此外，蝎毒可作为昆虫毒素，有望用作杀虫剂。本文综述了蝎毒毒素的种类，并讨论了它们在杀虫剂和治疗药物开发中的用途。
