Deligeorgopoulou Marianna, Tsabouri Sophia, Siomou Ekaterini, Vlahos Antonios P, Serbis Anastasios
Department of Pediatrics, University of Ioannina, 45110 Ioannina, Greece.
Children (Basel). 2025 Oct 9;12(10):1354. doi: 10.3390/children12101354.
Obesity and asthma are increasingly prevalent chronic conditions that often coexist in the pediatric population and may influence each other through shared pathophysiological mechanisms. Obesity can affect asthma expression and severity via mechanical effects on the lungs, systemic inflammation, altered adipokine levels, and metabolic dysregulation. These mechanisms contribute to a distinct asthma phenotype in children with obesity that is often less responsive to standard therapy. Nutrition plays a critical role in this context by influencing immune function, inflammation, and respiratory outcomes. Specific dietary patterns, such as the Mediterranean diet, along with nutrients including vitamin D, antioxidants, and polyunsaturated fatty acids, have been associated with the modulation of airway inflammation and asthma risk. Additionally, early-life nutritional exposures and gut microbiota composition may influence immune development and the propensity for allergic diseases. This narrative review aims to synthesize current evidence on the interplay between obesity, asthma, and nutrition in the pediatric population, highlighting potential dietary interventions and targets for improved asthma management in children with obesity.
肥胖和哮喘是日益普遍的慢性疾病,在儿科人群中常常并存,并且可能通过共同的病理生理机制相互影响。肥胖可通过对肺部的机械作用、全身炎症、脂肪因子水平改变和代谢失调来影响哮喘的表现和严重程度。这些机制导致肥胖儿童出现一种独特的哮喘表型,这种表型通常对标准治疗反应较差。在这种情况下,营养通过影响免疫功能、炎症和呼吸结局发挥关键作用。特定的饮食模式,如地中海饮食,以及包括维生素D、抗氧化剂和多不饱和脂肪酸在内的营养素,已与气道炎症的调节和哮喘风险相关联。此外,生命早期的营养暴露和肠道微生物群组成可能影响免疫发育和过敏性疾病的易感性。本叙述性综述旨在综合当前关于儿科人群中肥胖、哮喘和营养之间相互作用的证据,强调潜在的饮食干预措施以及改善肥胖儿童哮喘管理的靶点。