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大鼠实验性婴儿型多囊肾。年龄和性别的影响。

Experimental infantile polycystic kidney in rats. The influence of age and sex.

作者信息

McGeoch J E, Woodhouse M A, Darmady E M

出版信息

Br J Exp Pathol. 1972 Jun;53(3):322-40.

PMID:4115632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072463/
Abstract

The nephrotoxic effects of an anti-inflammatory compound 5,6,7,8 tetrahydrocarbozole-3-acetic acid in rats were found to be age and sex correlated. Morphologically the experimental lesion mimicked infantile polycystic disease. Application of the drug produced a lowering of the serum gamma globulins, a rise in the urinary protein and an increase in kidney weight associated with oedema and hyperplasia of the proximal and distal tubules.

摘要

一种抗炎化合物5,6,7,8-四氢咔唑-3-乙酸对大鼠的肾毒性作用被发现与年龄和性别相关。从形态学上看，实验性病变类似于婴儿多囊性疾病。该药物的应用导致血清γ球蛋白降低、尿蛋白增加以及肾脏重量增加，同时伴有近端和远端肾小管的水肿和增生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/8d9c5b32adef/brjexppathol00417-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/8eaae23a6ce0/brjexppathol00417-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/bfab766d0c29/brjexppathol00417-0121-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/0e07cf6c42c5/brjexppathol00417-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/6d78102bd64e/brjexppathol00417-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/8d9c5b32adef/brjexppathol00417-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/8eaae23a6ce0/brjexppathol00417-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/bfab766d0c29/brjexppathol00417-0121-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/0e07cf6c42c5/brjexppathol00417-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/6d78102bd64e/brjexppathol00417-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d75b/2072463/8d9c5b32adef/brjexppathol00417-0124-a.jpg

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Experimental infantile polycystic kidney in rats. The influence of age and sex.大鼠实验性婴儿型多囊肾。年龄和性别的影响。
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本文引用的文献

1
Polycystic Disease of the Kidney.多囊肾病
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Observations on familial polycystic disease of the kidney.关于肾家族性多囊病的观察
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3
A sex difference in the kidney glucuronidase activity of inbred mice.近交系小鼠肾脏葡萄糖醛酸酶活性的性别差异。
J Natl Cancer Inst. 1951 Feb;11(4):663-9.
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STUDIES ON THE TUBULAR ALTERATIONS IN DIFFUSE RENAL DISEASES. I. QUANTITATIVE EVALUATION OF THE CELLULARITY OF PROXIMAL CONVOLUTED TUBULES IN THE NORMAL KIDNEY.弥漫性肾脏疾病肾小管改变的研究。I. 正常肾脏近端曲管细胞数量的定量评估
Lab Invest. 1965 Mar;14:295-302.
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THE GROWTH AND MATURATION OF HUMAN GLOMERULI AND PROXIMAL CONVOLUTIONS FROM TERM TO ADULTHOOD: STUDIES BY MICRODISSECTION.从足月到成年期人类肾小球和近端曲管的生长与成熟：显微解剖研究
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PATHOGENESIS OF POLYCYSTIC KIDNEYS. TYPE 3 DUE TO MULTIPLE ABNORMALITIES OF DEVELOPMENT.多囊肾的发病机制。3型源于多种发育异常。
Arch Pathol. 1964 May;77:485-502.
7
PATHOGENESIS OF POLYCYSTIC KIDNEYS. TYPE 1 DUE TO HYPERPLASIA OF INTERSTITIAL PORTIONS OF COLLECTING TUBULES.多囊肾的发病机制。1型是由于集合管间质部分增生所致。
Arch Pathol. 1964 May;77:466-73.
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The structural and functional aspects of the handling of glucose by the nephrons and the kidney and their correlation by means of structural-functional equivalents.肾单位和肾脏对葡萄糖的处理的结构和功能方面，以及它们通过结构-功能等效物的相关性。
J Clin Invest. 1961 Jul;40(7):1093-112. doi: 10.1172/JCI104340.
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Microdissection of the nephron in disease.疾病状态下肾单位的显微切割
Br Med Bull. 1957 Jan;13(1):21-6. doi: 10.1093/oxfordjournals.bmb.a069564.
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Cystic disease of the kidneys. Autopsy report and family study.
Acta Pathol Microbiol Scand. 1965;64(4):459-69. doi: 10.1111/apm.1965.64.4.459.