Experimental infantile polycystic kidney in rats. The influence of age and sex.
作者信息
McGeoch J E, Woodhouse M A, Darmady E M
出版信息
Br J Exp Pathol. 1972 Jun;53(3):322-40.
Abstract
The nephrotoxic effects of an anti-inflammatory compound 5,6,7,8 tetrahydrocarbozole-3-acetic acid in rats were found to be age and sex correlated. Morphologically the experimental lesion mimicked infantile polycystic disease. Application of the drug produced a lowering of the serum gamma globulins, a rise in the urinary protein and an increase in kidney weight associated with oedema and hyperplasia of the proximal and distal tubules.
摘要
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