Princé H P, Ramsden D B
Clin Endocrinol (Oxf). 1977 Oct;7(4):307-24. doi: 10.1111/j.1365-2265.1977.tb01330.x.
A theoretical model is proposed which describes the binding of thyroid hormones to serum proteins in terms of easily determined parameters, Not only free hormone concentration but also the distribution of hormone among various binding sites may be computed. The mathematical approach is capable of dealing with models of differing complexity of binding from simple 'one binding site per protein molecule' systems to those involving 'negative co-operativity'. The approach gives predictions of thyroid function parameters which are in good agreement with those observed in practice.
提出了一种理论模型，该模型根据易于确定的参数描述甲状腺激素与血清蛋白的结合情况。不仅可以计算游离激素浓度，还可以计算激素在各种结合位点之间的分布。该数学方法能够处理从简单的“每个蛋白质分子一个结合位点”系统到涉及“负协同性”的不同结合复杂性模型。该方法给出的甲状腺功能参数预测与实际观察到的结果高度一致。
