Rosseel Zenzi, Overwater Noortje M P, Aerts Maridi, Chapple Lee-Anne S, Chen Dechang, Haines Krista L, Liu Jiao, Kouw Imre W K, Ke Lu, Pichard Claude, Ridley Emma J, Singer Pierre, Waitzberg Dan L, Li Weiqin, Wischmeyer Paul E, An Youzhong, van Zanten Arthur R H, Waele Elisabeth De
Brussels Health Campus, Faculty of Medicine and Pharmacy, Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels, 1090, Belgium.
Department of Pharmacy, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels Health Campus, Laarbeeklaan 101, Jette, Brussels, 1090, Belgium.
Crit Care. 2025 Oct 29;29(1):460. doi: 10.1186/s13054-025-05710-2.
While mortality for critically ill patients has decreased, many survivors face persistent physical, cognitive, and psychological impairments, collectively known as post-intensive care syndrome, which significantly reduce health-related quality of life (HRQoL). Nutrition is a crucial component of recovery, yet evidence-based strategies for post-intensive care unit (ICU) nutritional management remain underdeveloped.
The Global Research Initiative on Post-ICU Nutrition (GRIP) was established to address this gap by advancing research, education, and clinical practice in post-ICU nutrition. International experts in the field of critical care nutrition were invited to a diagnostic matrix meeting, to develop a definition of post-ICU patients relevant to GRIP, discuss emerging evidence regarding post-ICU nutritional management, and identify core research domains to guide future research.
The consortium consensus was achieved. A post-ICU patient is defined as any adult patient who has been admitted to an ICU for more than 48 h and is in the post-ICU recovery phase, which begins after the first ICU discharge and continues for up to one year, regardless of hospital length of stay, readmissions, or discharge destination. Ten core nutrition research domains were identified, including: (1) pathophysiology of post-ICU recovery, (2) phenotyping and personalised nutrition strategies, (3) timing and delivery of nutrition, (4) nutritional intake monitoring and optimisation, (5) nutrition interventions and effectiveness, (6) long-term functional and health-related quality of life outcomes, (7) digital tools and remote monitoring, (8) education and healthcare professional engagement, (9) implementation science and system integration, and (10) patient and family involvement.
GRIP envisions a future in which patients post-ICU receive personalised, timely, and effective nutritional care to enhance recovery, reduce complications, and improve long-term HRQoL. By identifying knowledge gaps, initiating targeted research projects, and supporting global educational efforts, GRIP aims to generate robust evidence, foster international collaboration, and strengthen clinical capacity to improve global post-ICU nutritional care.
尽管重症患者的死亡率有所下降，但许多幸存者仍面临持续的身体、认知和心理障碍，统称为重症后综合征，这显著降低了健康相关生活质量（HRQoL）。营养是康复的关键组成部分，但重症监护病房（ICU）营养管理的循证策略仍未充分发展。
成立了全球重症后营养研究倡议（GRIP），以通过推进重症后营养领域的研究、教育和临床实践来填补这一空白。重症监护营养领域的国际专家受邀参加一次诊断矩阵会议，以制定与GRIP相关的重症后患者定义，讨论有关重症后营养管理的新证据，并确定指导未来研究的核心研究领域。
达成了联盟共识。重症后患者定义为任何入住ICU超过48小时且处于重症后恢复阶段的成年患者，该阶段始于首次从ICU出院后，并持续长达一年，无论住院时间长短、再次入院情况或出院目的地如何。确定了十个核心营养研究领域，包括：（1）重症后恢复的病理生理学，（2）表型分析和个性化营养策略，（3）营养的时机和提供方式，（4）营养摄入监测和优化，（5）营养干预及其效果，（6）长期功能和健康相关生活质量结局，（7）数字工具和远程监测，（8）教育与医护人员参与，（9）实施科学与系统整合，以及（10）患者及家属参与。
GRIP设想了一个未来，即重症后患者能够获得个性化、及时且有效的营养护理，以促进康复、减少并发症并改善长期HRQoL。通过识别知识差距、启动针对性研究项目并支持全球教育工作，GRIP旨在生成有力证据、促进国际合作并加强临床能力，以改善全球重症后营养护理。
