Clark K G, Davidson W M
J Clin Pathol. 1972 Nov;25(11):947-50. doi: 10.1136/jcp.25.11.947.
Lipofuscins are commonly present in the macrophages of the marrow. In unstained preparations they may be confused with haemosiderin, but they are readily distinguished by fluorescence microscopy. In contrast to the belief that lipofuscins are a manifestation of senility, no age dependence has been demonstrated. Exceptionally large amounts have been found in illnesses accompanied by fever and leucocytosis, in keeping with the concept of their formation from insoluble remains of ingested cell fragments. It is probable that the ;sea-blue histiocytes', described in the literature, are macrophages laden with strikingly uniform granules of lipofuscin.
脂褐素通常存在于骨髓巨噬细胞中。在未染色的标本中，它们可能与含铁血黄素混淆，但通过荧光显微镜很容易区分。与脂褐素是衰老表现的观点相反，尚未证明其与年龄有关。在伴有发热和白细胞增多的疾病中发现了异常大量的脂褐素，这与它们由摄入的细胞碎片的不溶性残留物形成的概念相符。文献中描述的“海蓝色组织细胞”很可能是充满了非常均匀的脂褐素颗粒的巨噬细胞。
