Ylinen Venla, Valtonen Rasmus I P, Stenbäck Ville, Mäkelä Kari A, Näpänkangas Juha, Junttila M Juhani, Kerkelä Risto, Pöllänen Noora, Pirinen Eija, Herzig Karl-Heinz, Tulppo Mikko P
Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, PO Box 5000, FI-90014, Oulu, Finland.
Eur J Appl Physiol. 2025 Nov 6. doi: 10.1007/s00421-025-06032-5.
The inter-individual responses in systolic blood pressure (SBP) vary from no change to marked reduction after acute exercise. We hypothesized that skeletal muscle phenotype modifies SBP responses.
Normotensive participants (12 males and 8 females, age 27 ± 6 years) performed two 30-min exercises, continuous and interval, by cycle ergometer on separate days. The area under the curve (AUC) for SBP was calculated until 60 min after exercise. Intensity of continuous exercise was 60% of peak exercise workload and interval exercise 8 × 1 min intervals (80-90% of peak exercise workload) with 2 min easy cycling between. The average workload was equal for both exercises (60%). Stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR), and baroreflex sensitivity (BRS) were measured at rest and after exercise. Muscle biopsies were taken from vastus lateralis on separate days, and the percentage of slow/fast fibers, capillary density and mitochondrial respiration were analyzed.
AUC for SBP was - 386 ± 387 vs -399 ± 228 mmHg·min (p = 0.89) after continuous and interval exercises, respectively. After interval exercise, AUC correlated with the percentage of fast fibers (r = - 0.60, p = 0.010) and, eg, with ΔCO (r = 0.45, p = 0.049) and ΔBRS (r = 0.48, p = 0.046). In the stepwise linear regression analysis, the percentage of fast fibers was the strongest predictor of AUC after interval exercise (partial correlation r = - 0.53, β = - 5.9, p = 0.024). AUC after continuous exercise did not correlate with any outcomes.
Participants with a greater proportion of fast fibers had superior SBP reductions after interval exercise. The muscle phenotype is an independent determinant of postexercise SBP after interval exercise.
急性运动后，个体间收缩压（SBP）的反应各不相同，从无变化到显著降低。我们假设骨骼肌表型会改变SBP反应。
血压正常的参与者（12名男性和8名女性，年龄27±6岁）在不同日期通过自行车测力计进行两次30分钟的运动，分别是持续运动和间歇运动。计算运动后60分钟内SBP的曲线下面积（AUC）。持续运动的强度为最大运动负荷的60%，间歇运动为8×1分钟的间歇（最大运动负荷的80 - 90%），其间有2分钟的轻松骑行。两种运动的平均负荷相等（60%）。在静息和运动后测量每搏输出量（SV）、心输出量（CO）、全身血管阻力（SVR）和压力反射敏感性（BRS）。在不同日期从股外侧肌取肌肉活检样本，分析慢/快纤维百分比、毛细血管密度和线粒体呼吸。
持续运动和间歇运动后，SBP的AUC分别为 - 386±387与 - 399±228 mmHg·min（p = 0.89）。间歇运动后，AUC与快纤维百分比相关（r = - 0.60，p = 0.010），例如与ΔCO（r = 0.45，p = 0.049）和ΔBRS（r = 0.48，p = 0.046）相关。在逐步线性回归分析中，快纤维百分比是间歇运动后AUC的最强预测因子（偏相关r = - 0.53，β = - 5.9，p = 0.024）。持续运动后的AUC与任何结果均无相关性。
快纤维比例较高的参与者在间歇运动后SBP降低更显著。肌肉表型是间歇运动后运动后SBP的独立决定因素。
