Sun Yongtao, Guo Na, Fang Tinghao, Feng Yanyan, Liu Peng, Sun Dongfeng, Li Yongmeng, Liu Kexuan, Ren Yiyan, Li Minghui, Liu Qiuyue, Yang Xiaoling, Chi Yongliang, Liu Zhongkai, Yuan Li, Lang Bao, Yang Zaiqi, Feng Nianhai, You Peijun, Zhang Wensheng, Su Diansan, Wu Jianbo
Department of Anesthesiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Shandong Institute of Anesthesia and Respiratory Critical Medicine, Jinan, China.
Perioper Med (Lond). 2025 Nov 6;14(1):122. doi: 10.1186/s13741-025-00564-2.
Thoracic paravertebral block (TPVB) with liposomal bupivacaine (LB) is increasingly used for postoperative pain control in patients undergoing thoracic surgery, but relevant data are scarce, and there are few data on LB-TPVB combined with drainage tube patient-controlled analgesia (PCA). The aim of this study is to explore the effect of LB-TPVB combined with drainage-tube PCA on postoperative pain after thoracoscopic lobectomy.
This is a prospective, multicentre, double-blind, randomized controlled study. Participants will be randomly assigned to the standard bupivacaine (SB) group, SB + drainage-tube PCA (DTA) group, LB group, or LB + DTA group. The primary outcome is the 72-h mean Numerical Rating Scale (NRS) pain score at rest. The target sample size is 228 patients, with 57 patients in each group.
Our study hypothesizes that preoperative ultrasound-guided thoracic nerve block combined with drainage tube self-controlled analgesia is more effective in reducing postoperative pain following thoracoscopic lobe resection compared to thoracic nerve block alone. Additionally, liposomal bupivacaine was found to be more effective than standard bupivacaine in this context. These results will have implications for improving postoperative analgesia protocols for patients undergoing thoracoscopic lung surgery.
ClinicalTrials.gov, NCT06165991. Registered 29 November 2023, https://clinicaltrials.gov/study/NCT06165991 .
脂质体布比卡因（LB）用于胸段椎旁阻滞（TPVB）以控制胸科手术患者术后疼痛的情况日益增多，但相关数据匮乏，关于LB-TPVB联合引流管患者自控镇痛（PCA）的数据更是稀少。本研究旨在探讨LB-TPVB联合引流管PCA对胸腔镜肺叶切除术后疼痛的影响。
这是一项前瞻性、多中心、双盲、随机对照研究。参与者将被随机分配至标准布比卡因（SB）组、SB + 引流管PCA（DTA）组、LB组或LB + DTA组。主要结局指标为静息状态下72小时平均数字评定量表（NRS）疼痛评分。目标样本量为228例患者，每组57例。
我们的研究假设，与单纯胸段神经阻滞相比，术前超声引导下胸段神经阻滞联合引流管自控镇痛在减轻胸腔镜肺叶切除术后疼痛方面更有效。此外，在此背景下发现脂质体布比卡因比标准布比卡因更有效。这些结果将对改善胸腔镜肺手术患者的术后镇痛方案具有指导意义。
ClinicalTrials.gov，NCT06165991。于2023年11月29日注册，https://clinicaltrials.gov/study/NCT06165991 。
