Smith J B, Iverson G M
Clin Exp Immunol. 1973 Feb;13(2):209-12.
A liver-specific, water-soluble autoantigen (F-antigen) was detected by double diffu-ion using specifically prepared antiserum in thirty of 285 adult serum samples tested. F-antigen was found most frequently in disorders associated with hepatocellular destruction such as metastatic cancers (four of eleven patients) and viral hepatitis (eight of twenty-five). It was also found in serum from patients with cirrhosis (three of twenty-eight), steatonecrosis (two of thirteen) and hepatocellular carcinoma (two of eleven). These preliminary results suggest that further study of F-antigen in human disease states is warranted.
利用特制抗血清通过双向扩散法在285份成人血清样本中的30份中检测到一种肝脏特异性水溶性自身抗原（F抗原）。F抗原在与肝细胞破坏相关的疾病中最为常见，如转移性癌症（11例患者中有4例）和病毒性肝炎（25例中有8例）。在肝硬化患者（28例中有3例）、脂肪坏死（13例中有2例）和肝细胞癌患者（11例中有2例）的血清中也发现了该抗原。这些初步结果表明，有必要对人类疾病状态下的F抗原进行进一步研究。
