Meltzer H Y, Fessler R G, Fang V S
Psychopharmacology (Berl). 1977 Oct 20;54(2):183-6. doi: 10.1007/BF00426777.
Perlapine is a dibenzohetereopine compound chemically related to clothiapine, loxapine, and clozapine. Although the latter three compounds are antipsychotic, perlapine has not been reported to be antipsychotic. Nevertheless, all four drugs increase rat plasma prolactin levels. The order of potency is loxapine, perlapine, clothiapine, and clozapine. These results suggest that either perlapine should be reexamined for antipsychotic properties or there are hitherto unsuspected discrepancies between the dopamine receptors relevant to antipsychotic activity in man and those that regulate prolactin secretion in the rat.
奋乃静是一种二苯并杂环庚烷化合物，在化学结构上与氯噻平、洛沙平和氯氮平相关。尽管后三种化合物具有抗精神病作用，但尚未有报道称奋乃静具有抗精神病作用。然而，这四种药物都会使大鼠血浆催乳素水平升高。其效力顺序为洛沙平、奋乃静、氯噻平、氯氮平。这些结果表明，要么应重新研究奋乃静的抗精神病特性，要么在与人类抗精神病活性相关的多巴胺受体和调节大鼠催乳素分泌的多巴胺受体之间存在迄今未被怀疑的差异。
