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体外肿瘤细胞排斥反应。

Rejection of tumor cells in vitro.

作者信息

Berczi I, Strausbauch P, Sehon A H

出版信息

Science. 1973 Jun 22;180(4092):1289-91. doi: 10.1126/science.180.4092.1289.

DOI:10.1126/science.180.4092.1289
PMID:4122513
Abstract

The emergence of lymphoblast-like cells, capable of rapidly destroying tumor cells, was observed in primary cultures of an antigenic sarcoma transplantable in strain 13 guinea pigs. It is likely that these cytotoxic cells represent the progeny of lymphocytes sensitive to tutmor antigens that had infiltrated the tumor tissue.

摘要

在可移植于13号品系豚鼠的抗原性肉瘤的原代培养物中,观察到了能够快速破坏肿瘤细胞的淋巴母细胞样细胞的出现。这些细胞毒性细胞很可能代表了已浸润肿瘤组织的对肿瘤抗原敏感的淋巴细胞的后代。

相似文献

1
Rejection of tumor cells in vitro.体外肿瘤细胞排斥反应。
Science. 1973 Jun 22;180(4092):1289-91. doi: 10.1126/science.180.4092.1289.
2
In vitro activity of subpopulations of immune lymphocytes against murine sarcoma cells.免疫淋巴细胞亚群对小鼠肉瘤细胞的体外活性。
Transplantation. 1974 Oct;18(4):368-71. doi: 10.1097/00007890-197410000-00012.
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Solubilized tumour-associated antigens of methyl-cholanthrene-induced mouse sarcomas. Comparative studies by in vitro sensitization of lymph-node cells, macrophage electrophoretic mobility assay and transplantation tests.甲基胆蒽诱导的小鼠肉瘤的可溶性肿瘤相关抗原。通过淋巴结细胞体外致敏、巨噬细胞电泳迁移率测定和移植试验进行的比较研究。
Int J Cancer. 1978 Mar 15;21(3):348-55. doi: 10.1002/ijc.2910210316.
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Selective reaction of effector lymphocytes of transplantation immunity to private specificities of the H-2K and H-2D loci.移植免疫效应淋巴细胞对H-2K和H-2D位点私有特异性的选择性反应。
Bull Exp Biol Med. 1974 Dec;77(6):659-62. doi: 10.1007/BF00789995.
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Efferent enhancement of a methylcholanthrene-induced sarcoma transplantable in strain 13 guinea pigs.甲基胆蒽诱导的可移植于13号品系豚鼠的肉瘤的传出增强作用
Eur J Immunol. 1976 Jun;6(6):453-5. doi: 10.1002/eji.1830060614.
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Cell-mediated cytotoxicity of adherent and non-adherent mouse lymph node cells sensitized in vitro against tumour-associated antigens of syngenetic methylcholanthrene-induced sarcomas.体外致敏的贴壁和非贴壁小鼠淋巴结细胞对同基因甲基胆蒽诱导肉瘤的肿瘤相关抗原的细胞介导细胞毒性。
Folia Biol (Praha). 1979;25(2):137-41.
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Phenotypes associated with tumor rejection mediated by cyclophosphamide and syngeneic tumor-sensitized T lymphocytes: potential mechanisms of action.与环磷酰胺和同基因肿瘤致敏T淋巴细胞介导的肿瘤排斥相关的表型:潜在作用机制
Int J Cancer. 1984 Mar 15;33(3):381-8. doi: 10.1002/ijc.2910330317.
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Tumor-specific and allospecific immunogenicity of soluble extracts from chemically induced murine sarcomas.化学诱导的小鼠肉瘤可溶性提取物的肿瘤特异性和同种特异性免疫原性。
J Immunol. 1974 Aug;113(2):708-11.
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Proceedings: Immunologic similarities between fetal cell antigens and tumor cell antigens in guinea pigs.论文集:豚鼠胎儿细胞抗原与肿瘤细胞抗原之间的免疫学相似性
Cancer. 1974 Feb;33(2):376-83. doi: 10.1002/1097-0142(197402)33:2<376::aid-cncr2820330212>3.0.co;2-r.
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The effect of curative cryosurgery on the tumor-specific immune response of C57 mice.
Cryobiology. 1975 Apr;12(2):175-9. doi: 10.1016/s0011-2240(75)80010-1.

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