人腓肠神经在体外对多巴胺-β-羟化酶的轴突运输
Axonal transport of dopamine- -hydroxylase by human sural nerves in vitro.
作者信息
Brimijoin S, Capek P, Dyck P J
出版信息
Science. 1973 Jun 22;180(4092):1295-7. doi: 10.1126/science.180.4092.1295.
PMID:4122514
Abstract
Dopamine-beta-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-beta-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.
摘要
在体外培养的正常人腓肠神经活检样本中，结扎线以上的多巴胺-β-羟化酶活性会累积。累积速率表明该酶以每小时2毫米的速度向远端运输。一些患有周围神经病变患者的腓肠神经中，多巴胺-β-羟化酶的轴浆运输显著减少。
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