人抗IgM同种抗体：IgM 同种异型标记物的检测
Human anti-IgM iso-antibodies: detection of IgM allotypic markers.
作者信息
Wells J V, Bleumers J F, Fudenberg H H
出版信息
Proc Natl Acad Sci U S A. 1973 Mar;70(3):827-9. doi: 10.1073/pnas.70.3.827.
IgG class antibodies against human IgM were detected in a human subject up to a titer of 1:1024 against 5 of a group of 23 monoclonal Waldenström macroglobulins. Inhibition studies confirmed at least one antigenic determinant shared by the 5 IgMs. The determinant was present on the mu chain but required tertiary structure for its full expression. Inhibition of the reaction between the antibodies to IgM and erythrocytes coated with 2 of the 5 IgMs was obtained at titers of 1:2 to 1:16 with 51.0% of 300 normal sera (85.2% of sera from 122 Caucasian, 26.1% of sera from 23 Negro, and 27.7% of sera from 155 Japanese individuals). This inhibition was independent of the serum IgM concentration. Family studies indicated that the determinant was inherited according to basic Mendelian laws and appears to be the first allotypic marker on human serum IgM. We have designated it Mm 1.
在一名人类受试者体内检测到了针对人IgM的IgG类抗体，针对一组23种单克隆瓦尔登斯特伦巨球蛋白中的5种，其滴度高达1:1024。抑制研究证实这5种IgM至少有一个共同的抗原决定簇。该决定簇存在于μ链上，但需要三级结构才能完全表达。用300份正常血清中的51.0%（122名白种人血清的85.2%、23名黑人血清的26.1%和155名日本人血清的27.7%），在1:2至1:16的滴度下可抑制针对IgM的抗体与包被有5种IgM中2种的红细胞之间的反应。这种抑制与血清IgM浓度无关。家系研究表明，该决定簇按照基本孟德尔定律遗传，似乎是人类血清IgM上的首个同种异型标记。我们将其命名为Mm 1。
Zotero 插件